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Overview

  • Product namePCK2 peptideSee all PCK2 proteins and peptides ...
  • Protein descriptionSynthetic peptide derived from within residues 400 - 500 of Human PCK2.(Note: the amino acid sequence is proprietary)This peptide was used as an immunogen for ab70359 - PCK2 antibody.
  • Protein length640 amino acids

    • Properties

  • Purity70 - 90% by HPLC
  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferInformation available upon request.
  • Concentration information loading...
  • Research Areas

    • Applications

  • Application notesThis peptide can be used with studies using ab70359.

    • Protein info

    • Alternative names
        EC 4.1.1.32GTP mitochondrial precursorHGNC:8725
        mitochondrialMitochondrial phosphoenolpyruvate carboxykinase 2OTTHUMP00000164700PCK2PCKGM_HUMANPEPEP carboxykinasePEPCKPEPCK deficiency mitochondrialPEPCK MPEPCK-MPEPCK2Phosphoenolpyruvate carboxykinase [GTP]Phosphoenolpyruvate carboxykinase 2 (mitochondrial)Phosphoenolpyruvate carboxykinase 2 mitochondrialPhosphoenolpyruvate carboxylasePhosphopyruvate carboxylase
      see all
  • FunctionCatalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
  • PathwayCarbohydrate biosynthesis; gluconeogenesis.
  • Involvement in diseaseDefects in PCK2 are the cause of mitochondrial phosphoenolpyruvate carboxykinase deficiency (M-PEPCKD) [MIM:261650]. A metabolic disorder resulting from impaired gluconeogenesis. It is a rare disease with less than 10 cases reported in the literature. Clinical characteristics include hypotonia, hepatomegaly, failure to thrive, lactic acidosis and hypoglycemia. Autoposy reveals fatty infiltration of both the liver and kidneys. The disorder is transmitted as an autosomal recessive trait.
  • Sequence similaritiesBelongs to the phosphoenolpyruvate carboxykinase [GTP] family.
  • Post-translational
    modifications    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localizationMitochondrion.

    • Target information above from: UniProt accession Q16822 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    References for PCK2 peptide (ab87120)

    ab87120 has not yet been referenced specifically in any publications.

    Publishing research using ab87120 ? Please let us know so that we can cite the reference in this datasheet

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