Anti-PCSK9 antibody (ab52755)

Overview

• Product nameAnti-PCSK9 antibodySee all PCSK9 primary antibodies ...
• Description
  Rabbit polyclonal to PCSK9
• SpecificityDetects both the zymogen and mature forms of PC9. Smaller cleavage products are also detected.
• Tested applicationsWB more details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  Synthetic peptide based on the propeptide domain of human PC9

• EpitopeThe epitope is aminoterminal from the propeptide cleave site.

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Storage bufferPreservative: 0.05% Sodium Azide
  Constituents: 50% Glycerol, PBS, 500mM Sodium chloride
• Concentration information loading...
• PurityImmunogen affinity purified
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Metabolism
  • Pathways and Processes
  • Metabolic signaling pathways
  • Amino acid metabolism

  • Metabolism
  • Types of disease
  • Cancer

  • Metabolism
  • Pathways and Processes
  • Metabolic signaling pathways
  • Lipid and lipoprotein metabolism
  • Cholesterol Metabolism

  • Stem Cells
  • Neural Stem Cells
  • Intracellular

  • Signal Transduction
  • Metabolism
  • Lipid metabolism

  • Signal Transduction
  • Metabolism
  • Amino Acids

  • Cardiovascular
  • Lipids / Lipoproteins
  • Lipid Metabolism
  • Cholesterol Metabolism

  • Cell Biology
  • Proteolysis / Ubiquitin
  • Proteolytic enzymes
  • Serine protease
  • Proprotein Convertases

Applications

Target

• FunctionMay be implicated in the differentiation of cortical neurons and may play a role in cholesterol homeostasis.
• Tissue specificityExpressed in neuro-epithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells.
• Involvement in diseaseDefects in PCSK9 are the cause of familial hypercholesterolemia 3 (FH3) [MIM:603776]. FH3 inheritance is autosomal dominant.
• Sequence similaritiesBelongs to the peptidase S8 family.
  Contains 1 peptidase S8 domain.
• Post-translational
  modificationsThe soluble zymogen undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted enzyme.
• Cellular localizationSecreted.

Target information above from: UniProt accession Q8NBP7 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 255738 Human
  • Omim: 607786 Human
  • SwissProt: Q8NBP7 Human
  • Unigene: 18844 Human

• Alternative names
  Convertase subtilisin/kexin type 9 preproprotein antibodyFH3 antibodyHCHOLA3 antibody

  Hypercholesterolemia autosomal dominant 3 antibodyLDLCQ1 antibodyNARC 1 antibodyNARC-1 antibodyNARC1 antibodyNeural apoptosis regulated convertase 1 antibodyNeural apoptosis-regulated convertase 1 antibodyPC 9 antibodyPC9 antibodyPCSK 9 antibodyPCSK9 antibodyPCSK9_HUMAN antibodyProprotein convertase 9 antibodyProprotein convertase PC9 antibodyProprotein convertase subtilisin/kexin type 9 antibodyPSEC0052 antibodySubtilisin/kexin like protease PC9 antibodySubtilisin/kexin-like protease PC9 antibody

  see all

Anti-PCSK9 antibody images

• 

  Western blot - PCSK9 antibody (ab52755)
  All lanes : Anti-PCSK9 antibody (ab52755) at 1/1000 dilution
  
  Lane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell Lysate
  Lane 2 : HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell Lysate
  
  Lysates/proteins at 10 µg per lane.
  
  Secondary
  Goat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution
  
  Predicted band size : 74 kDa
  Observed band size : 74 kDa