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Anti-PDE4A antibody (ab14607)

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Overview

Product name

Anti-PDE4A antibody
See all PDE4A products (6) ...

Description

Rabbit polyclonal to PDE4A

Specificity

This antibody labels all known PDE4A variants including PDE4A1 (66 kDa), A5 (109 kDa), A8 (106 kDa), Ax (102 kDa) and a 76 kDa testis specific A variant.

Tested applications

ICC/IF, WB, IP, ICC, IFmore details

Cross reactivity

Reacts with

Mouse, Rat, Rabbit, Human

Immunogen

Synthetic peptide corresponding to the C-terminal region of PDE4A (common to all PDE4A proteins).

Positive control

recombinant protein (PDE4A1, PDE4A5, PDE4A8, PDE4A10, PDE4A11)

Properties

Form

Liquid

Storage instructions

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Concentration

Concentration information loading...

Purity

Immunogen affinity purified

Clonality

Polyclonal

Isotype

IgG

Research areas

Signal Transduction >> Second Messenger >> Nucleotide Messenger >> cAMP

Applications

Show applications key

Our Abpromise guarantee covers the use of ab14607 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Target

Function

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.

Tissue specificity

Isoform 1 is widely expressed. Isoform 2 is abundant in liver, stomach, testis, thyroid and adrenal glands. It is also found in placenta, kidney, pancreas, ovary, uterus, skin, monocytes, mast cells, macrophages, as well as in bronchial smooth muscle. Isoform 6 is expressed at high levels in the heart and small intestine. It is also found in the brain, kidney, spleen, colon, salivary gland, ovary and peripheral blood lymphocytes. Isoform 7 is expressed predominantly in skeletal muscle and brain and at lower levels in the testis. Isoform 7 is expressed in the brain. Found in specific neuronal subpopulations in cortex, spinal cord and cerebellum (at protein level).

Pathway

Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.

Sequence similarities

Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.

Post-translational
modifications

Phosphorylated at Ser-686 and Ser-688 when expressed in S.frugiperda cells. Isoform 2 and isoform 7 are activated by phosphorylation at Ser-119 and Ser-123 respectively by PKA.
Proteolytically cleaved by caspase-3.

Cellular localization

Cytoplasm > perinuclear region; Cytoplasm > perinuclear region. Cell projection > ruffle membrane; Cytoplasm. Membrane. Predominantly cytoplasmic and Membrane. Isoform 4 has propensity for association with membranes.

Target information above from: UniProt accessionP27815 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • 5''-cyclic phosphodiesterase 4A antibody
  • cAMP specific 3 5 cyclic phosphodiesterase 4A antibody
  • cAMP specific phosphodiesterase antibody
  • cAMP-specific 3'' antibody
  • cAMP-specific 3',5'-cyclic phosphodiesterase 4A antibody
  • DPDE2 antibody
  • dunce like phosphodiesterase E2 antibody
  • PDE 4A antibody
  • PDE4 antibody
  • PDE46 antibody
  • PDE4A antibody
  • PDE4A_HUMAN antibody
  • PDE4A11 antibody
  • Phosphodiesterase 4A antibody
  • phosphodiesterase 4A cAMP specific antibody
  • phosphodiesterase E2 dunce homolog antibody
  • phosphodiesterase isozyme 4 antibody
  • phosphodiesterase type 4A11 antibody
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Database links

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References for Anti-PDE4A antibody (ab14607)

This product has been referenced in:

  • Lee AC  et al. Olfactory marker protein is critical for functional maturation of olfactory sensory neurons and development of mother preference. J Neurosci 31:2974-82 (2011).Read more (PubMed: 21414919) »
  • Kolosionek E  et al. Expression and activity of phosphodiesterase isoforms during epithelial mesenchymal transition: the role of phosphodiesterase 4. Mol Biol Cell 20:4751-65 (2009). WB, ICC/IF; Human.Read more (PubMed: 19759179) »

See all 5 publications for this product

Publishing research using ab14607? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"