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Products:Signal Transduction >> Second Messenger >> Nucleotide Messenger >> cAMP
Overview
Product name
PDE6 beta peptide
See all PDE6 beta products (2) ...
Properties
Purity
>95% by SDS-PAGE
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Concentration
Concentration information loading...
Sequence notes
A 17 amino acid synthetic peptide whose sequence is derived from mouse PDE6 beta protein. The sequence of this peptide is (amino to carboxy terminus): Synthetic Peptide: H(20) QYFG(K/R)K LSPENVAGA C(36)
Research areas
Neuroscience >> Sensory System >> Visual system
Signal Transduction >> Second Messenger >> Nucleotide Messenger >> cGMP
Signal Transduction >> Second Messenger >> Nucleotide Messenger >> cAMP
Applications
Show applications key
Our Abpromise guarantee covers the use of ab5890 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
BL: Use at an assay dependent dilution.
Application notes
This peptide can be used with studies using ab5663.
Protein info
Function
This protein participates in processes of transmission and amplification of the visual signal. Necessary for the formation of a functional phosphodiesterase holoenzyme.
Involvement in disease
Defects in PDE6B are the cause of retinitis pigmentosa type 40 (RP40) [MIM:613801]. RP40 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
Defects in PDE6B are a cause of congenital stationary night blindness autosomal dominant type 2 (CSNBAD2) [MIM:163500]; also known as congenital stationary night blindness Rambusch type. Congenital stationary night blindness is a non-progressive retinal disorder characterized by impaired night vision.
Sequence similarities
Belongs to the cyclic nucleotide phosphodiesterase family.
Contains 2 GAF domains.
Cellular localization
Membrane.
Target information above from: UniProt accessionP35913
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
References for PDE6 beta peptide (ab5890)
ab5890 has not yet been referenced specifically in any publications.
Publishing research using ab5890? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"