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PDGF AA protein (Active) (ab9702)

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Overview

  • Product namePDGF AA protein (Active)See all PDGF AA proteins and peptides ...
  • Protein descriptionHighly pure (>98%) recombinant human PDGF AA.
  • Expression hostE. coli

    • Properties

  • Purification notesSterile filtered Greater than 98% pure by SDS-PAGE and HPLC analyses. Endotoxin level is less than 0.1 ng per µg (1EU/µg).
  • FormLyophilised
  • Storage instructionsStore at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.This product is an active protein and may elicit a biological response in vivo, handle with caution.
  • Concentration information loading...
  • Additional notesThe biological activity is determined by the dose-dependent stimulation of the proliferation of BALB/c 3T3 cells, is < 1.0 ng/ml, corresponding to a specific activity of > 1 x 106 units/mg
  • Sequence notesHuman PDGF-AA is a 28.5 kDa A chain homodimer protein containing 250 amino acid residues: SIEEAVPAVC KTRTVIYEIP RSQVDPTSAN FLIWPPCVEV KRCTGCCNTS SVKCQPSRVH HRSVKVAKVE YVRKKPKLKE VQVRLEEHLE CACATTSLNP DYREEDTGRP RESGKKRKRK RLKPT
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab9702 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    Functional Studies FuncS: Use at an assay dependent dilution.
    SDS-PAGE SDS-PAGE: Use at an assay dependent dilution.
  • Application notesThis peptide can be used with studies using ab9701.

    • Protein info

    • Alternative names
        PDGF A chainPDGF subunit APDGF-1
        PDGF1PDGFAPDGFA_HUMANPlatelet derived growth factor A chain precursorPlatelet derived growth factor alpha polypeptidePlatelet-derived growth factor A chainPlatelet-derived growth factor alpha polypeptidePlatelet-derived growth factor subunit A
      see all
  • FunctionPlatelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. Binding of this growth factor to its receptor elicits a variety of cellular responses. It is released by platelets upon wounding and plays an important role in stimulating adjacent cells to grow and thereby heals the wound.
  • Sequence similaritiesBelongs to the PDGF/VEGF growth factor family.
  • DomainThe long form contains a basic insert which acts as a cell retention signal.
  • Cellular localizationSecreted.

    • Target information above from: UniProt accession P04085 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    References for PDGF AA protein (Active) (ab9702)

    ab9702 has not yet been referenced specifically in any publications.

    Publishing research using ab9702 ? Please let us know so that we can cite the reference in this datasheet

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    Dear technical team,

    Our company has order a PDGF ELISA (ab100622) Kit from abcam. We would like to have a positive control of human (and murine) PDGF-A. Do you know where we can find one of them?

    Regards,

    Thank for your enquiry and interest.





    I would like to confirm the this kit contains 2 vials of Standards: recombinant human PDGF-AA





    However, currently we also have we have 4 products PDGF AA...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"