Anti-PDGF Receptor alpha antibody (ab124392)

Overview

• Product nameAnti-PDGF Receptor alpha antibodySee all PDGF Receptor alpha primary antibodies ...
• Description
  Rabbit polyclonal to PDGF Receptor alpha
• Tested applicationsWB, IP, IHC-P more details
• Species reactivity
  Reacts with: Mouse, Human
  Predicted to work with: Rat, Rabbit, Horse, Chicken, Cow, Dog, Pig, Xenopus laevis
• Immunogen

  Synthetic peptide:C-GKRNRHSSQTSEESAIETG conjugated to KLH, corresponding to amino acids 1035-1053 of Human PDGF Receptor alpha.

  Run BLAST with Run BLAST with
• Positive controlHuman brain, cerebellum tissue; NIH/3T3 cell line lysate

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Storage bufferpH: 7.40
  Preservative: 0.05% Sodium azide
  Constituents: 99% Tris glycine, 0.88% Sodium chloride
• Concentration information loading...
• PurityImmunogen affinity purified
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Cancer
  • Growth factors
  • PDGF

  • Cancer
  • Oncoproteins/suppressors
  • Oncoproteins
  • Growth factor receptors

  • Signal Transduction
  • Growth Factors/Hormones
  • PDGF

  • Signal Transduction
  • Protein Phosphorylation
  • Tyrosine Kinases
  • Receptor Tyrosine Kinases

  • Cardiovascular
  • Atherosclerosis
  • Vascular Inflammation
  • Inflammatory mediators

  • Cardiovascular
  • Angiogenesis
  • Growth Factors
  • Other

Applications

Target

• FunctionReceptor that binds both PDGFA and PDGFB and has a tyrosine-protein kinase activity.
• Tissue specificityExpressed in primary and metastatic colon tumors and in normal colon tissue. Tumors may express a different isoform to that found in normal tissue.
• Involvement in diseaseNote=A chromosomal aberration involving PDGFRA is found in some cases of hypereosinophilic syndrome. Interstitial chromosomal deletion del(4)(q12q12) causes the fusion of FIP1L1 and PDGFRA (FIP1L1-PDGFRA).
• Sequence similaritiesBelongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
  Contains 5 Ig-like C2-type (immunoglobulin-like) domains.
  Contains 1 protein kinase domain.
• Cellular localizationMembrane.

Target information above from: UniProt accession P16234 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 5156 Human
  • Entrez Gene: 18595 Mouse
  • Entrez Gene: 25267 Rat
  • Omim: 173490 Human
  • SwissProt: P16234 Human
  • SwissProt: P26618 Mouse
  • SwissProt: P20786 Rat
  • SwissProt: P26619 Xenopus laevis

  • Unigene: 74615 Human
  • Unigene: 221403 Mouse
  • Unigene: 55127 Rat
  • Unigene: 20029 Xenopus laevis

  see all

• Alternative names
  Alpha-type platelet-derived growth factor receptor antibodyCD140 antigen-like family member A antibodyCD140a antibody

  CD140a antigen antibodyMGC74795 antibodyPDGF alpha chain antibodyPDGF-R-alpha antibodyPDGFR 2 antibodyPDGFR alpha antibodyPDGFR2 antibodyPDGFRA antibodyPDGFRA/BCR fusion antibodyPGFRA_HUMAN antibodyPlatelet derived growth factor receptor 2 antibodyPlatelet derived growth factor receptor alpha antibodyPlatelet derived growth factor receptor alpha polypeptide antibodyPlatelet derived growth factor receptor antibodyRearranged in hypereosinophilia platelet derived growth factor receptor alpha fusion protein antibodyRHEPDGFRA antibody

  see all

Anti-PDGF Receptor alpha antibody images

• 

  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PDGF Receptor alpha antibody (ab124392)
  ab124392, at 1/100 dilution, staining PDGF Receptor alpha in formalin-fixed, paraffin-embedded Human brain cerebellum tissue by Immunohistochemistry.