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PDGF Receptor beta protein (Active) (ab60833)

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Overview

  • Product namePDGF Receptor beta protein (Active)See all PDGF Receptor beta proteins and peptides ...
  • Protein descriptionRecombinant fragment, corresponding to amino acids 557-end of Human PDGF Receptor beta, was expressed by baculovirus in Sf9 insect cells using a N-terminal tag, MW 104kDa.
  • Expression hostInsect cells

    • Properties

  • Purity> 90 % by SDS-PAGE
  • Purification notesPurity: >90% as determined by densitometry.
  • FormLiquid
  • Storage instructionsShipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.This product is an active protein and may elicit a biological response in vivo, handle with caution.
  • Storage bufferPreservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
  • Concentration information loading...
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab60833 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    Functional Studies
    SDS-PAGE
  • Application notesFuncS: Kinase assay: Use at an assay dependent dilution.

    Specific Activity: 20 nmol/min/mg.


    SDS-PAGE: Use at an assay dependent dilution.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.

    • Protein info

    • Alternative names
        Beta platelet derived growth factor receptorBeta-type platelet-derived growth factor receptorCD 140B
        CD140 antigen-like family member BCD140BCD140bCD140b antigenIBGC4JTK12OTTHUMP00000160528PDGF R betaPDGF-R-betaPDGFRPDGFR 1PDGFR betaPDGFR1PDGFRBPGFRB_HUMANPlatelet derived growth factor receptor 1Platelet derived growth factor receptor betaPlatelet derived growth factor receptor beta polypeptide
      see all
  • FunctionReceptor that binds specifically to PDGFB and PDGFD and has a tyrosine-protein kinase activity. Phosphorylates Tyr residues at the C-terminus of PTPN11 creating a binding site for the SH2 domain of GRB2.
  • Involvement in diseaseNote=A chromosomal aberration involving PDGFRB is found in a form of chronic myelomonocytic leukemia (CMML). Translocation t(5;12)(q33;p13) with EVT6/TEL. It is characterized by abnormal clonal myeloid proliferation and by progression to acute myelogenous leukemia (AML).
    Note=A chromosomal aberration involving PDGFRB may be a cause of acute myelogenous leukemia. Translocation t(5;14)(q33;q32) with TRIP11. The fusion protein may be involved in clonal evolution of leukemia and eosinophilia.
    Note=A chromosomal aberration involving PDGFRB may be a cause of juvenile myelomonocytic leukemia. Translocation t(5;17)(q33;p11.2) with SPECC1.
    Defects in PDGFRB are a cause of myeloproliferative disorder chronic with eosinophilia (MPE) [MIM:131440]. A hematologic disorder characterized by malignant eosinophils proliferation. Note=A chromosomal aberration involving PDGFRB is found in many instances of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;12) with ETV6 on chromosome 12 creating an PDGFRB-ETV6 fusion protein.
    Note=A chromosomal aberration involving PDGFRB may be the cause of a myeloproliferative disorder (MBD) associated with eosinophilia. Translocation t(1;5)(q23;q33) that forms a PDE4DIP-PDGFRB fusion protein.
  • Sequence similaritiesBelongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
    Contains 5 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 protein kinase domain.
  • Post-translational
    modifications    Autophosphorylated. Dephosphorylated by PTPRJ at Tyr-751, Tyr-857, Tyr-1009 and Tyr-1021.
  • Cellular localizationMembrane.

    • Target information above from: UniProt accession P09619 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    PDGF Receptor beta protein (Active) images

    • Functional Studies - PDGF Receptor beta protein (Cytoplasmic domain) (ab60833)
      Functional Studies - PDGF Receptor beta protein (Cytoplasmic domain) (ab60833)
      Sample Kinase Activity Plot.
    • SDS-PAGE - PDGF Receptor beta protein (Cytoplasmic domain) (ab60833)
      SDS-PAGE - PDGF Receptor beta protein (Cytoplasmic domain) (ab60833)
      ab60833 on SDS-PAGE, MW ~104kDa.

    References for PDGF Receptor beta protein (Active) (ab60833)

    ab60833 has not yet been referenced specifically in any publications.

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