PDGF Receptor beta protein (Active) (ab60833)
Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
Our Abpromise guarantee covers the use of ab60833 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Specific Activity: 20 nmol/min/mg.
SDS-PAGE: Use at an assay dependent dilution.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
- Beta platelet derived growth factor receptorBeta-type platelet-derived growth factor receptorCD 140B
- CD140 antigen-like family member BCD140BCD140bCD140b antigenIBGC4JTK12OTTHUMP00000160528PDGF R betaPDGF-R-betaPDGFRPDGFR 1PDGFR betaPDGFR1PDGFRBPGFRB_HUMANPlatelet derived growth factor receptor 1Platelet derived growth factor receptor betaPlatelet derived growth factor receptor beta polypeptide
Note=A chromosomal aberration involving PDGFRB may be a cause of acute myelogenous leukemia. Translocation t(5;14)(q33;q32) with TRIP11. The fusion protein may be involved in clonal evolution of leukemia and eosinophilia.
Note=A chromosomal aberration involving PDGFRB may be a cause of juvenile myelomonocytic leukemia. Translocation t(5;17)(q33;p11.2) with SPECC1.
Defects in PDGFRB are a cause of myeloproliferative disorder chronic with eosinophilia (MPE) [MIM:131440]. A hematologic disorder characterized by malignant eosinophils proliferation. Note=A chromosomal aberration involving PDGFRB is found in many instances of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;12) with ETV6 on chromosome 12 creating an PDGFRB-ETV6 fusion protein.
Note=A chromosomal aberration involving PDGFRB may be the cause of a myeloproliferative disorder (MBD) associated with eosinophilia. Translocation t(1;5)(q23;q33) that forms a PDE4DIP-PDGFRB fusion protein.
Contains 5 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 protein kinase domain.
modificationsAutophosphorylated. Dephosphorylated by PTPRJ at Tyr-751, Tyr-857, Tyr-1009 and Tyr-1021.
PDGF Receptor beta protein (Active) images
Sample Kinase Activity Plot.
ab60833 on SDS-PAGE, MW ~104kDa.
References for PDGF Receptor beta protein (Active) (ab60833)
ab60833 has not yet been referenced specifically in any publications.