Anti-AS3 antibody (ab84918)
Key features and details
- Rabbit polyclonal to AS3
- Suitable for: IHC-P
- Reacts with: Mouse, Human
- Isotype: IgG
Overview
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Product name
Anti-AS3 antibody
See all AS3 primary antibodies -
Description
Rabbit polyclonal to AS3 -
Host species
Rabbit -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Mouse, Human
Predicted to work with: Chimpanzee, Gorilla, Orangutan -
Immunogen
Synthetic peptide corresponding to Human AS3 aa 1200-1300.
Database link: Q9NTI5 -
Positive control
- Human controls: Breast Carcinoma, Ovarian Carcinoma, Prostate Carcinoma, Skin Basal Cell Carcinoma, Testicular Seminoma Mouse control: Squamous Cell Carcinoma
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
pH: 6.8
Preservative: 0.09% Sodium azide
Constituents: 0.1% BSA, Tris buffered saline -
Concentration information loading...
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Purity
Immunogen affinity purified -
Purification notes
ab84918 was affinity purified using an epitope specific to AS3 immobilized on solid support. Antibody concentration was determined by extinction coefficient: absorbance at 280 nm of 1.4 equals 1.0 mg of IgG. -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab84918 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IHC-P |
Notes |
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Likely to work with frozen sections.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
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Function
Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells. -
Tissue specificity
Widely expressed. -
Sequence similarities
Belongs to the PDS5 family.
Contains 3 A.T hook DNA-binding domains.
Contains 1 HEAT repeat. -
Cellular localization
Nucleus. - Information by UniProt
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Database links
- Entrez Gene: 23047 Human
- Entrez Gene: 100710 Mouse
- Omim: 605333 Human
- SwissProt: Q9NTI5 Human
- SwissProt: Q4VA53 Mouse
- Unigene: 744901 Human
- Unigene: 32959 Mouse
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Alternative names
- AI646570 antibody
- Androgen induced proliferation inhibitor antibody
- Androgen-induced proliferation inhibitor antibody
see all
Images
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ab84918, at a 1/100 dilution, staining AS3 in formalin fixed, paraffin embedded human prostate carcinoma by Immunohistochemistry. Detection: a Red fluorescent goat anti-rabbit IgG highly cross adsorbed antibody at a dilution of 1/100.
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ab84918, at a 1/250 dilution, staining AS3 in formalin fixed, paraffin embedded human prostate carcinoma by Immunohistochemistry, using DAB staining.
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ab84918, at a 1/250 dilution, staining AS3 in formalin fixed, paraffin embedded mouse squamous cell carcinoma by Immunohistochemistry, using DAB staining.
Datasheets and documents
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SDS download
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Datasheet download
References (1)
ab84918 has been referenced in 1 publication.
- Brieño-Enríquez MA et al. Cohesin Removal along the Chromosome Arms during the First Meiotic Division Depends on a NEK1-PP1?-WAPL Axis in the Mouse. Cell Rep 17:977-986 (2016). PubMed: 27760328