Anti-PGP9.5 antibody (ab72910)
- Product nameAnti-PGP9.5 antibodySee all PGP9.5 primary antibodies ...
- DescriptionChicken polyclonal to PGP9.5
- Tested applicationsWB, ICC/IF more details
- Species reactivityReacts with: Mouse, Rat, Cow, Human
Recombinant full length human PGP9.5 purified from E. coli.
- Positive control
- Rat hippocampal homogenate and Rat mixed neuron/glial cultures.
- Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
- Storage bufferPreservative: 10mM Sodium Azide
- Concentration information loading...
- PurityIgY fraction
- Clonality Polyclonal
- Research Areas
Our Abpromise guarantee covers the use of ab72910 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||WB: 1/2500. Detects a band of approximately 25 kDa (predicted molecular weight: 25 kDa).|
- FunctionUbiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity.
- Tissue specificityFound in neuronal cell bodies and processes throughout the neocortex (at protein level). Expressed in neurons and cells of the diffuse neuroendocrine system and their tumors. Weakly expressed in ovary. Down-regulated in brains from Parkinson disease and Alzheimer disease patients.
- Involvement in diseaseDefects in UCHL1 are the cause of Parkinson disease type 5 (PARK5) [MIM:613643]; also known as Parkinson disease autosomal dominant 5. PARK5 is a complex neurodegenerative disorder with manifestations ranging from typical Parkinson disease to dementia with Lewy bodies. Clinical features include parkinsonian symptoms (resting tremor, rigidity, postural instability and bradykinesia), dementia, diffuse Lewy body pathology, autonomic dysfunction, hallucinations and paranoia.
- Sequence similaritiesBelongs to the peptidase C12 family.
- Cellular localizationCytoplasm. Endoplasmic reticulum membrane. About 30% of total UCHL1 is associated with membranes in brain.
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Anti-PGP9.5 antibody images
Anti-PGP9.5 antibody (ab72910) at 1/2500 dilution + rat hippocampal homogenate
Predicted band size : 25 kDa
Observed band size : 25 kDa
ab72910 at 1/500 dilution staining PGP9.5 in rat mixed neuron/glial cultures by Immunofluorescence (green). Rabbit anti-GFAP antibody (red). Blue is a DNA stain.
References for Anti-PGP9.5 antibody (ab72910)
This product has been referenced in:
- Fu YY et al. 3-D imaging and illustration of mouse intestinal neurovascular complex. Am J Physiol Gastrointest Liver Physiol 304:G1-11 (2013). ICC/IF ; Mouse . Read more (PubMed: 23086917) »
- Allen C et al. Neutrophil cerebrovascular transmigration triggers rapid neurotoxicity through release of proteases associated with decondensed DNA. J Immunol 189:381-92 (2012). Read more (PubMed: 22661091) »