Overview

  • Product name
    PI 103
  • Description
    Potent cell-permeable PI3K inhibitor
  • Biological description
    Potent, cell-permeable ATP-competitive PI3K inhibitor (IC50 values are 2, 8, 20, 26, 48, 83, 88 and 150 nM for DNA-PK, p110α, mTORC1, PI3-KC2β, p110δ, mTORC2, p110β, and p110γ, respectively). Shows antiproliferative effects against cancer cell lines. Shows antitumor effects in vivo.
  • Purity
    > 95%

Properties

References

This product has been referenced in:
  • Duan Q  et al. Role of phosphoinositide 3-kinase IA (PI3K-IA) activation in cardioprotection induced by ouabain preconditioning. J Mol Cell Cardiol 80C:114-125 (2015). Read more (PubMed: 25575882) »
  • Gedaly R  et al. PI-103 and sorafenib inhibit hepatocellular carcinoma cell proliferation by blocking Ras/Raf/MAPK and PI3K/AKT/mTOR pathways. Anticancer Res 30:4951-8 (2010). Read more (PubMed: 21187475) »
  • Park S  et al. PI-103, a dual inhibitor of Class IA phosphatidylinositide 3-kinase and mTOR, has antileukemic activity in AML. Leukemia 22:1698-706 (2008). Read more (PubMed: 18548104) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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