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Products:Neuroscience >> Neurotransmission >> Secretory Vesicles >> Regulation
Overview
Product name
Anti-PICK1 antibody
See all PICK1 products (7) ...
Description
Rabbit polyclonal to PICK1
Specificity
Recognizes PICK1.
Tested applications
Cross reactivity
Reacts with
Mouse, Rat
Immunogen
6xhis tagged fusion protein: EKMELLDQKH VQDIVFQLQR FVSTMSKYYN DCYAVLQDAD VFPIEVDLAH TTLAYGPNQG SFTDGEEEDE EEEDGAAREV SKDACGATGP TDKGGSWCDS, corresponding to C terminal amino acids 317-416 of Mouse PICK1.
EKMELLDQKH VQDIVFQLQR FVSTMSKYYN DCYAVLQ DAD VFPIEVDLAH TTLAYGPNQG SFTDGEEEDE EEE DGAAREV SKDACGATGP TDKGGSWCDS
Positive control
RIPA lysates from rat brain microsomal preparation.
Properties
Form
Liquid
Storage instructions
Add glycerol to a final volume of 50%, aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 0.05% Sodium Azide
Constituents: 5mg/ml BSA, 0.15M Sodium Chloride, 50mM Glycine, 0.2mM Tris, 0.1mM EDTA. pH 7.4
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Signal Transduction >> Protein Trafficking >> Vesicle Transport >> Regulation
Signal Transduction >> Protein Phosphorylation >> Tyrosine Kinases >> Receptor Tyrosine Kinases
Signal Transduction >> Protein Phosphorylation >> Ser / Thr Kinases >> PKC
Neuroscience >> Neurotransmission >> Secretory Vesicles >> Regulation
Applications
Show applications key
Our Abpromise guarantee covers the use of ab15001 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: 1/500 - 1/1000.Predicted molecular weight: 50 kDa.
Target
Function
Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate heteromeric ACCN3/ACCN2 channel.
Tissue specificity
Ubiquitous.
Sequence similarities
Contains 1 AH domain.
Contains 1 PDZ (DHR) domain.
Post-translational
modifications
Phosphorylation at Thr-82 appears to inhibit the interaction with AMPA receptors.
Cellular localization
Cytoplasm > perinuclear region. Cell junction > synapse. Also present at excitatory synapses.
Target information above from: UniProt accessionQ9NRD5
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- dJ1039K5 antibody
- MGC15204 antibody
- OTTHUMP00000028509 antibody
see all
Database links
- Entrez Gene: 18693 Mouse
- Entrez Gene: 84591 Rat
- SwissProt: Q62083 Mouse
- SwissProt: Q9EP80 Rat
- Unigene: 259464 Mouse
- Unigene: 24750 Rat
References for Anti-PICK1 antibody (ab15001)
ab15001 has not yet been referenced specifically in any publications.
Publishing research using ab15001? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"