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Products:Neuroscience >> Neurotransmission >> Secretory Vesicles >> Regulation
Overview
Product name
Anti-PICK1 antibody
See all PICK1 products (7) ...
Description
Mouse monoclonal to PICK1
Tested applications
Cross reactivity
Reacts with
Human
Immunogen
Recombinant fragment, corresponding to amino acids 266-376 of Human PICK1
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
PBS, pH 7.2
Concentration
Concentration information loading...
Purity
Protein G purified
Clonality
Monoclonal
Isotype
IgG2a
Light chain type
kappa
Research areas
Signal Transduction >> Protein Trafficking >> Vesicle Transport >> Regulation
Signal Transduction >> Protein Phosphorylation >> Tyrosine Kinases >> Receptor Tyrosine Kinases
Signal Transduction >> Protein Phosphorylation >> Ser / Thr Kinases >> PKC
Neuroscience >> Neurotransmission >> Secretory Vesicles >> Regulation
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Western blot - PICK1 antibody (ab56586)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab56586 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- 1 Image
WB
Application notes
WB: Use at a concentration of 1-5 µg/ml.
This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Function
Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate heteromeric ACCN3/ACCN2 channel.
Tissue specificity
Ubiquitous.
Sequence similarities
Contains 1 AH domain.
Contains 1 PDZ (DHR) domain.
Post-translational
modifications
Phosphorylation at Thr-82 appears to inhibit the interaction with AMPA receptors.
Cellular localization
Cytoplasm > perinuclear region. Cell junction > synapse. Also present at excitatory synapses.
Target information above from: UniProt accessionQ9NRD5
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- dJ1039K5 antibody
- MGC15204 antibody
- OTTHUMP00000028509 antibody
see all
Database links
- Entrez Gene: 9463 Human
- Omim: 605926 Human
- SwissProt: Q9NRD5 Human
- Unigene: 180871 Human
Anti-PICK1 antibody images:
Western blot - PICK1 antibody (ab56586)
Western blot against tagged recombinant protein immunogen using ab56586 PICK1 antibody at 1ug/ml. Predicted band size of immunogen is 38 kDa
References for Anti-PICK1 antibody (ab56586)
ab56586 has not yet been referenced specifically in any publications.
Publishing research using ab56586? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"