Anti-PIK3R5 antibody (ab111152)

Overview

• Product nameAnti-PIK3R5 antibodySee all PIK3R5 primary antibodies ...
• Description
  Rabbit polyclonal to PIK3R5
• Tested applicationsIHC-P more details
• Species reactivity
  Reacts with: Human
  Predicted to work with: Mouse
• Immunogen

  Synthetic peptide derived from a region within internal sequence of Human PIK3R5.

• Positive controlParaffin embedded Human colon carcinoma tissue

Properties

• FormLiquid
• Storage instructionsStore at -20°C. Stable for 12 months at -20°C
• Storage bufferpH: 7.40
  Preservative: 0.02% Sodium azide
  Constituents: PBS, 0.88% Sodium chloride, 50% Glycerol
  Note: without Mg2+ and Ca2+
• Concentration information loading...
• PurityImmunogen affinity purified
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Signal Transduction
  • Signaling Pathway
  • Lipid Signaling
  • Lipid Kinases

Applications

Target

• FunctionRegulatory subunit of the PI3K gamma complex.
• Tissue specificityUbiquitously expressed with high expression in fetal brain compared to adult brain. Abundant expression is observed in cerebellum, cerebral cortex, cerebral meninges, and vermis cerebelli.
• Involvement in diseaseNote=Defects in PIK3R5 may be a cause of autosomal recessive ataxia with oculomotor apraxia (AOA). A PIK3R5 mutation segregates with the disease phenotype in a family affected by gait ataxia, cerebellar dysarthric speech, and impaired ocular movement. Additional features include reduced or absent tendon reflexes, severe cerebellar atrophy, marked vermal atrophy, moderately severe axonal sensory polyneuropathy with absent sensory nerve action potential in the lower extremities, and persistently elevated alpha-fetoprotein levels.
• DomainThe heterodimerization region allows the binding to the catalytic subunit.
• Cellular localizationNucleus. Cytoplasm. Membrane.

Target information above from: UniProt accession Q8WYR1 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 23533 Human
  • Entrez Gene: 320207 Mouse
  • Omim: 611317 Human
  • SwissProt: Q8WYR1 Human
  • SwissProt: Q5SW28 Mouse
  • Unigene: 278901 Human
  • Unigene: 738684 Human
  • Unigene: 244960 Mouse

• Alternative names
  5-bisphosphate 3-kinase regulatory subunit antibodyF730038I15Rik antibodyFOAP 2 antibody

  FOAP2 antibodyOTTHUMP00000135339 antibodyp101 antibodyP101 PI3K antibodyp101-PI3K antibodyPhosphatidylinositol 4 antibodyPhosphatidylinositol 4,5 bisphosphate 3 kinase regulatory subunit antibodyPhosphoinositide 3 kinase, regulatory subunit 5 antibodyPhosphoinositide 3 kinase, regulatory subunit 5, p101 antibodyPhosphoinositide 3 kinase, regulatory subunit, polypeptide p101 antibodyPhosphoinositide 3-kinase regulatory subunit 5 antibodyPI3 kinase p101 subunit antibodyPI3 kinase regulatory subunit 5 antibodyPI3-kinase p101 subunit antibodyPI3-kinase regulatory subunit 5 antibodyPI3R5_HUMAN antibodyPIK3 R5 antibodyPIK3R5 antibodyProtein FOAP 2 antibodyProtein FOAP-2 antibodyPtdIns 3 kinase p101 antibodyPtdIns 3 kinase regulatory subunit antibodyPtdIns-3-kinase p101 antibodyPtdIns-3-kinase regulatory subunit antibody

  see all

Anti-PIK3R5 antibody images

• 

  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - PIK3R5 antibody (ab111152)
  ab111152, at 1/50, staining PIK3R5 in Human colon carcinoma tissue by Immunohistochemistry.