Overview

  • Product nameAnti-PIK3R5 antibodySee all PIK3R5 primary antibodies ...
  • Description
    Rabbit polyclonal to PIK3R5
  • Tested applicationsIHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide derived from a region within internal sequence of Human PIK3R5.

  • Positive control
    • Paraffin embedded Human colon carcinoma tissue

Properties

  • FormLiquid
  • Storage instructionsStore at -20°C. Stable for 12 months at -20°C
  • Storage bufferpH: 7.40
    Preservative: 0.02% Sodium azide
    Constituents: PBS, 0.88% Sodium chloride, 50% Glycerol
    Note: without Mg2+ and Ca2+
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • Clonality Polyclonal
  • IsotypeIgG
  • Research Areas

Applications

Our Abpromise guarantee covers the use of ab111152 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • FunctionRegulatory subunit of the PI3K gamma complex.
  • Tissue specificityUbiquitously expressed with high expression in fetal brain compared to adult brain. Abundant expression is observed in cerebellum, cerebral cortex, cerebral meninges, and vermis cerebelli.
  • Involvement in diseaseNote=Defects in PIK3R5 may be a cause of autosomal recessive ataxia with oculomotor apraxia (AOA). A PIK3R5 mutation segregates with the disease phenotype in a family affected by gait ataxia, cerebellar dysarthric speech, and impaired ocular movement. Additional features include reduced or absent tendon reflexes, severe cerebellar atrophy, marked vermal atrophy, moderately severe axonal sensory polyneuropathy with absent sensory nerve action potential in the lower extremities, and persistently elevated alpha-fetoprotein levels.
  • DomainThe heterodimerization region allows the binding to the catalytic subunit.
  • Cellular localizationNucleus. Cytoplasm. Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • 5-bisphosphate 3-kinase regulatory subunit antibody
    • F730038I15Rik antibody
    • FOAP 2 antibody
    • FOAP2 antibody
    • OTTHUMP00000135339 antibody
    • p101 antibody
    • P101 PI3K antibody
    • p101-PI3K antibody
    • Phosphatidylinositol 4 antibody
    • Phosphatidylinositol 4,5 bisphosphate 3 kinase regulatory subunit antibody
    • Phosphoinositide 3 kinase, regulatory subunit 5 antibody
    • Phosphoinositide 3 kinase, regulatory subunit 5, p101 antibody
    • Phosphoinositide 3 kinase, regulatory subunit, polypeptide p101 antibody
    • Phosphoinositide 3-kinase regulatory subunit 5 antibody
    • PI3 kinase p101 subunit antibody
    • PI3 kinase regulatory subunit 5 antibody
    • PI3-kinase p101 subunit antibody
    • PI3-kinase regulatory subunit 5 antibody
    • PI3R5_HUMAN antibody
    • PIK3 R5 antibody
    • PIK3R5 antibody
    • Protein FOAP 2 antibody
    • Protein FOAP-2 antibody
    • PtdIns 3 kinase p101 antibody
    • PtdIns 3 kinase regulatory subunit antibody
    • PtdIns-3-kinase p101 antibody
    • PtdIns-3-kinase regulatory subunit antibody
    see all

Anti-PIK3R5 antibody images

  • ab111152, at 1/50, staining PIK3R5 in Human colon carcinoma tissue by Immunohistochemistry.

References for Anti-PIK3R5 antibody (ab111152)

ab111152 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"