Anti-PINK1 antibody (ab33250)

Overview

• Product nameAnti-PINK1 antibodySee all PINK1 primary antibodies ...
• Description
  Rabbit polyclonal to PINK1
• Tested applicationsWB more details
• Species reactivity
  Reacts with: Human
  Predicted to work with: Mouse, Rat
• Immunogen

  Synthetic peptide: YRKSKRGPKQLAPHPNI, corresponding to amino acids 258 - 274 of Human PINK1.

  Run BLAST with Run BLAST with

Properties

• FormLiquid
• Storage instructionsStore at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Storage bufferPreservative: 0.02% Sodium Azide
  Constituents: PBS
• Concentration information loading...
• PurityImmunogen affinity purified
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Metabolism
  • Types of disease
  • Neurodegenerative disease

  • Metabolism
  • Pathways and Processes
  • Mitochondrial Metabolism
  • Mitophagy fission and fusion

  • Metabolism
  • Pathways and Processes
  • Mitochondrial Metabolism
  • Mitochondrial markers

  • Metabolism
  • Types of disease
  • Cancer

  • Signal Transduction
  • Protein Phosphorylation
  • Ser / Thr Kinases
  • Other Kinases

  • Signal Transduction
  • Metabolism
  • Mitochondrial

  • Neuroscience
  • Neurology process
  • Neurodegenerative disease
  • Parkinson's disease
  • Other

Applications

Target

• FunctionProtects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). It is necessary for PARK2 recruitement to dysfunctional mitochondria to initiate their degradation.
• Tissue specificityHighly expressed in heart, skeletal muscle and testis, and at lower levels in brain, placenta, liver, kidney, pancreas, prostate, ovary and small intestine. Present in the embryonic testis from an early stage of development.
• Involvement in diseaseDefects in PINK1 are the cause of Parkinson disease type 6 (PARK6) [MIM:605909]. A neurodegenerative disorder characterized by parkinsonian signs such as rigidity, resting tremor and bradykinesia. A subset of patients manifest additional symptoms including hyperreflexia, autonomic instability, dementia and psychiatric disturbances. Symptoms show diurnal fluctuation and can improve after sleep.
• Sequence similaritiesBelongs to the protein kinase superfamily. Ser/Thr protein kinase family.
  Contains 1 protein kinase domain.
• Post-translational
  modificationsAutophosphorylated.
• Cellular localizationMitochondrion outer membrane. Cytoplasm > cytosol.

Target information above from: UniProt accession Q9BXM7 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 65018 Human
  • Entrez Gene: 68943 Mouse
  • Entrez Gene: 298575 Rat
  • NCBI: 14165272 Human
  • Omim: 608309 Human
  • SwissProt: Q9BXM7 Human
  • SwissProt: Q99MQ3 Mouse
  • Unigene: 389171 Human

  • Unigene: 18539 Mouse

  see all

• Alternative names
  BRPK antibodyFLJ27236 antibodymitochondrial antibody

  PARK 6 antibodyPARK6 antibodyPhosphatase and Tensin Homolog antibodyPINK 1 antibodyPINK1 antibodyPINK1_HUMAN antibodyProtein kinase BRPK antibodyPTEN induced putative kinase 1 antibodyPTEN induced putative kinase protein 1 antibodyPTEN-induced putative kinase protein 1 antibodySerine/threonine kinase PINK1 mitochondrial antibodySerine/threonine protein kinase PINK1 mitochondrial antibodySerine/threonine-protein kinase PINK1 antibody

  see all