Overview

  • Product namePK11195
  • Description
    Peripheral benzodiazepine receptor antagonist
  • Biological descriptionAntagonist at the mitochondrial (peripheral) benzodiazepine receptor (translocator protein, TSPO). Acts as a chemosensitizer of tumor cells to a wide range of chemotherapeutic agents.
  • Purity> 99%

Properties

    References for PK11195 (ab120378)

    This product has been referenced in:
    • Walter RB  et al. PK11195, a peripheral benzodiazepine receptor (pBR) ligand, broadly blocks drug efflux to chemosensitize leukemia and myeloma cells by a pBR-independent, direct transporter-modulating mechanism. Blood 106:3584-93 (2005). Read more (PubMed: 16051742) »
    • Casellas P  et al. Peripheral benzodiazepine receptors and mitochondrial function. Neurochem Int 40:475-86 (2002). Read more (PubMed: 11850104) »
    • Funakoshi T  et al. In vivo receptor labeling of peripheral benzodiazepine receptor by ex vivo binding of [3H]PK11195. Res Commun Mol Pathol Pharmacol 105:35-41 (1999). Read more (PubMed: 10850367) »

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"