Overview

  • Product nameAnti-PLA2G4D antibodySee all PLA2G4D primary antibodies ...
  • Description
    Mouse polyclonal to PLA2G4D
  • Tested applicationsWBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    PLA2G4D (AAH34571, 1 a.a. ~ 216 a.a) human protein.

  • Positive control
    • PLA2G4D transfected 293T lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab69368 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Detects a band of approximately 26 kDa (predicted molecular weight: 25 kDa).

Target

  • FunctionCalcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. Not arachidonic acid-specific but has linoleic acid-specific activity. May play a role in inflammation in psoriatic lesions.
  • Tissue specificityExpressed in stratified squamous epithelia, such as those in skin and cervix, but not in other tissues. Strongly expressed in the upper spinous layer of the psoriatic epidermis, expressed weakly and discontinuously in atopic dermatitis and mycosis fungoides, and not detected in the epidermis of normal skin.
  • Sequence similaritiesContains 1 C2 domain.
    Contains 1 PLA2c domain.
  • DomainThe N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+).
  • Cellular localizationCytoplasm > cytosol. Cytoplasmic vesicle membrane. Translocates to membrane vesicles in a calcium-dependent fashion. Translocates to perinuclear regions upon ionomycin stimulation.
  • Information by UniProt
  • Database links
  • Alternative names
    • cPLA2 delta antibody
    • cPLA2-delta antibody
    • cPLA2delta antibody
    • Cytosolic phospholipase A2 delta antibody
    • PA24D_HUMAN antibody
    • Phospholipase A2 group IVD antibody
    • phospholipase A2, group IVD (cytosolic) antibody
    • Pla2g4d antibody
    see all

Anti-PLA2G4D antibody images

  • All lanes : Anti-PLA2G4D antibody (ab69368) at 1/500 dilution

    Lane 1 : PLA2G4D transfected 293T lysate
    Lane 2 : Non-transfected 293T lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution

    Predicted band size : 25 kDa
    Observed band size : 26 kDa (why is the actual band size different from the predicted?)

References for Anti-PLA2G4D antibody (ab69368)

ab69368 has not yet been referenced specifically in any publications.

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