Anti-PPAP2A antibody (ab198280)
Key features and details
- Rabbit polyclonal to PPAP2A
- Suitable for: IHC-P, WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-PPAP2A antibody
See all PPAP2A primary antibodies -
Description
Rabbit polyclonal to PPAP2A -
Host species
Rabbit -
Tested applications
Suitable for: IHC-P, WBmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat -
Immunogen
Synthetic peptide corresponding to Human PPAP2A (internal sequence). (NP_003702).
Database link: O14494 -
Positive control
- Human liver cancer tissue lysate; Human breast cancer tissue.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.4
Preservative: 0.05% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab198280 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IHC-P |
1/25 - 1/100.
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WB |
1/500 - 1/2000. Predicted molecular weight: 32 kDa.
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Notes |
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IHC-P
1/25 - 1/100. |
WB
1/500 - 1/2000. Predicted molecular weight: 32 kDa. |
Target
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Function
Broad-specificity phosphohydrolase that dephosphorylates exogenous bioactive glycerolipids and sphingolipids. Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). Pivotal regulator of lysophosphatidic acid (LPA) signaling in the cardiovascular system. Major enzyme responsible of dephosphorylating LPA in platelets, which terminates signaling actions of LPA. May control circulating, and possibly also regulate localized, LPA levels resulting from platelet activation. It has little activity towards ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA > PA > S-1-P > C-1-P. It's down-regulation may contribute to the development of colon adenocarcinoma. -
Tissue specificity
Ubiquitously expressed with highest expression found in prostate. Isoform 1 is predominant in kidney, lung, placenta and liver. Isoform 2 is predominant in heart and pancreas. Found to be down-regulated in colon adenocarcinomas. -
Sequence similarities
Belongs to the PA-phosphatase related phosphoesterase family. -
Post-translational
modificationsN-glycosylated. Contains high-mannose oligosaccharides. -
Cellular localization
Cell membrane. - Information by UniProt
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Database links
- Entrez Gene: 8611 Human
- Entrez Gene: 19012 Mouse
- Entrez Gene: 64369 Rat
- Omim: 607124 Human
- SwissProt: O14494 Human
- SwissProt: Q61469 Mouse
- SwissProt: O08564 Rat
- Unigene: 696231 Human
see all -
Alternative names
- Lipid phosphate phosphohydrolase 1 antibody
- Lipid phosphate phosphohydrolase 1a antibody
- LLP1a antibody
see all
Images
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (2)
ab198280 has been referenced in 2 publications.
- Huang Q et al. Stimulated phospholipid synthesis is key for hepatitis B virus replications. Sci Rep 9:12989 (2019). PubMed: 31506451
- Hu Q et al. Lipid profile of platelets and platelet-derived microparticles in ovarian cancer. BBA Clin 6:76-81 (2016). WB ; Human . PubMed: 27453821