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Overview

  • Product namePPAR alpha peptideSee all PPAR alpha proteins and peptides ...

    • Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Concentration information loading...
  • Sequence notesA 12 amino acid synthetic peptide whose sequence is derived from mouse PPAR alpha protein with serine 12 being phosphorylated. The sequence of this peptide is (amino to carboxy terminus): Synthetic Peptide: I(8)CP(pS)PLEADDL(19).
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab4998 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    Blocking BL: Use at an assay dependent concentration.
  • Application notesThis peptide can be used with studies using ab3484.

    • Protein info

    • Alternative names
        hPPARMGC2237MGC2452
        NR1C1Nuclear receptor subfamily 1 group C member 1OTTHUMP00000197740OTTHUMP00000197741Peroxisome Proliferator Activated Receptor alphaPeroxisome proliferator-activated receptor alphaPPARPPAR-alphaPPARAPPARA_HUMANPPARalpha
      see all
  • FunctionLigand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety (By similarity). Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2.
  • Tissue specificitySkeletal muscle, liver, heart and kidney.
  • Sequence similaritiesBelongs to the nuclear hormone receptor family. NR1 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • Cellular localizationNucleus.

    • Target information above from: UniProt accession Q07869 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    References for PPAR alpha peptide (ab4998)

    ab4998 has not yet been referenced specifically in any publications.

    Publishing research using ab4998 ? Please let us know so that we can cite the reference in this datasheet

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