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Anti-PPAR alpha (phospho S12) antibody (ab3484)

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Overview

Product name

Anti-PPAR alpha (phospho S12) antibody
See all PPAR alpha products (11) ...

Description

Rabbit polyclonal to PPAR alpha (phospho S12)

Tested applications

ICC/IF, WBmore details

Cross reactivity

Reacts with

Mouse, Rat

Immunogen

Synthetic peptide: ICPLSpPLEADDL, corresponding to amino acids 8-19 of Mouse PPAR alpha.

ICPLSpPLEA DDL

Run BLAST with BLAST the sequence with ExPASyRun BLAST with BLAST the sequence with NCBI

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

PBS, 1 mg/ml BSA and 0.05% sodium azide

Concentration

Concentration information loading...

Purity

Immunogen affinity purified

Clonality

Polyclonal

Isotype

IgG

Research areas

Cancer >> Cancer Metabolism >> Response to hypoxia
Cancer >> Cancer Metabolism >> Metabolic signaling pathway >> Metabolism of lipids and lipoproteins
Cardiovascular >> Lipids / Lipoproteins >> Fatty Acids >> Metabolism
Cancer >> Signal transduction >> Nuclear signaling >> Nuclear hormone receptors >> Other
Epigenetics and Nuclear Signaling >> Transcription >> Domain Families >> Zinc Finger

  • Immunocytochemistry/ Immunofluorescence - PPAR alpha (phospho S12) antibody (ab3484)Immunocytochemistry/ Immunofluorescence - PPAR alpha (phospho S12) antibody (ab3484) image (enlarge)

Applications

Show applications key

Our Abpromise guarantee covers the use of ab3484 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Target

Function

Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety (By similarity). Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2.

Tissue specificity

Skeletal muscle, liver, heart and kidney.

Sequence similarities

Belongs to the nuclear hormone receptor family. NR1 subfamily.
Contains 1 nuclear receptor DNA-binding domain.

Cellular localization

Nucleus.

Target information above from: UniProt accessionQ07869 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • hPPAR antibody
  • MGC2237 antibody
  • MGC2452 antibody
  • NR1C1 antibody
  • Nuclear receptor subfamily 1 group C member 1 antibody
  • OTTHUMP00000197740 antibody
  • OTTHUMP00000197741 antibody
  • Peroxisome Proliferator Activated Receptor alpha antibody
  • Peroxisome proliferator-activated receptor alpha antibody
  • PPAR antibody
  • PPAR-alpha antibody
  • PPARA antibody
  • PPARA_HUMAN antibody
  • PPARalpha antibody
see all

Database links

Anti-PPAR alpha (phospho S12) antibody images:

  Immunocytochemistry/ Immunofluorescence - PPAR alpha (phospho S12) antibody (ab3484)

Immunocytochemistry/ Immunofluorescence - PPAR alpha (phospho S12) antibody (ab3484)

ab3484 staining PPAR alpha (phospho S12) in Mouse neuronal cells by ICC/IF (Immunocytochemistry/immunofluorescence). Cells were fixed with paraformaldehyde and blocked with 10% serum for 20 minutes at 25°C. Samples were incubated with primary antibody (1/100 in PBS) for 18 hours at 4°C. A Cy2®-conjugated Donkey anti-rabbit IgG polyclonal (1/100) was used as the secondary antibody.

This image is courtesy of an anonymous Abreview

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References for Anti-PPAR alpha (phospho S12) antibody (ab3484)

This product has been referenced in:

  • Qiu Let al. Inhibition of Aldose Reductase Activates Hepatic Peroxisome Proliferator-Activated Receptor-a and Ameliorates Hepatosteatosis in Diabetic db/db Mice. Exp Diabetes Res 2012:789730 (2012). WB; Mouse.Read more (PubMed: 22110479) »
  • Jansen Set al. Glucose deprivation, oxidative stress and peroxisome proliferator-activated receptor-alpha (PPARA) cause peroxisome proliferation in preimplantation mouse embryos. Reproduction 138:493-505 (2009).Read more (PubMed: 19531609) »

See all 4 publications for this product

Publishing research using ab3484? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"