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Anti-PPAR gamma antibody (ab48583)

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Overview

  • Product nameAnti-PPAR gamma antibodySee all PPAR gamma primary antibodies ...
  • Description
    Chicken polyclonal to PPAR gamma
  • SpecificityThis antibody reacts specifically with the PPAR gamma protein.
  • Tested applicationsWB more details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Dog, Pig, Cynomolgus Monkey, Rhesus monkey
  • Immunogen

    Synthetic peptide: YYSEKTQLYNKPHEE, corresponding to internal sequence amino acids 115-129 of Human PPAR gamma

    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
  • Positive controlHuman adipose lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab48583 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB WB: 1/2000 - 1/5000. Detects a band of approximately 58 kDa (predicted molecular weight: 58 kDa).

Target

  • FunctionReceptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis.
  • Tissue specificityHighest expression in adipose tissue. Lower in skeletal muscle, spleen, heart and liver. Also detectable in placenta, lung and ovary.
  • Involvement in diseaseNote=Defects in PPARG can lead to type 2 insulin-resistant diabetes and hyptertension. PPARG mutations may be associated with colon cancer.
    Defects in PPARG may be associated with susceptibility to obesity (OBESITY) [MIM:601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.
    Defects in PPARG are the cause of familial partial lipodystrophy type 3 (FPLD3) [MIM:604367]. Familial partial lipodystrophies (FPLD) are a heterogeneous group of genetic disorders characterized by marked loss of subcutaneous (sc) fat from the extremities. Affected individuals show an increased preponderance of insulin resistance, diabetes mellitus and dyslipidemia.
    Genetic variations in PPARG can be associated with susceptibility to glioma type 1 (GLM1) [MIM:137800]. Gliomas are central nervous system neoplasms derived from glial cells and comprise astrocytomas, glioblastoma multiforme, oligodendrogliomas, and ependymomas. Note=Polymorphic PPARG alleles have been found to be significantly over-represented among a cohort of American patients with sporadic glioblastoma multiforme suggesting a possible contribution to disease susceptibility.
  • Sequence similaritiesBelongs to the nuclear hormone receptor family. NR1 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • Cellular localizationNucleus.

    • Target information above from: UniProt accession P37231 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
    see all
  • Alternative names
      CIMT1 antibodyGLM1 antibodyHUMPPARG antibody
      NR1C3 antibodyNuclear receptor subfamily 1 group C member 3 antibodyOTTHUMP00000185032 antibodyOTTHUMP00000185036 antibodyPAX8/PPARG Fusion Gene antibodyPeroxisome proliferator activated nuclear receptor gamma variant 1 antibodyPeroxisome proliferator activated receptor gamma 1 antibodyPeroxisome Proliferator Activated Receptor gamma antibodyPeroxisome proliferator-activated receptor gamma antibodyPPAR gamma antibodyPPAR-gamma antibodyPPARG antibodyPPARG_HUMAN antibodyPPARG1 antibodyPPARG2 antibodyPPARG3 antibody
    see all

References for Anti-PPAR gamma antibody (ab48583)

ab48583 has not yet been referenced specifically in any publications.

Publishing research using ab48583 ? Please let us know so that we can cite the reference in this datasheet

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