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Anti-PR3 antibody [1B10] (ab10197)

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Overview

Product name

Anti-PR3 antibody [1B10]
See all PR3 products (14) ...

Description

Mouse monoclonal [1B10] to PR3

Specificity

ab10197, 10198, 10199, 10200 and 10201 detect different determinants of proteinase PR3 which have not been fully determined.

Tested applications

ELISAmore details

Cross reactivity

Reacts with

Human

Immunogen

Human proteinase PR3 purified leukocyte mass.

General notes

Concentration varies from lot to lot and can be provided on request.

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Storage buffer

Preservative: 0.1% Sodium Azide
Constituents: PBS, pH 7.4

Concentration

Concentration information loading...

Purity

Protein A purified

Purification notes

Purified by chromatography on protein A sepharose. Purity is tested by electrophoresis.

Clonality

Monoclonal

Clone number

1B10

Myeloma

Sp2/0

Isotype

IgG2a

Research areas

Signal Transduction >> Cytoskeleton / ECM >> Extracellular Matrix >> ECM Enzymes >> Other Enzymes
Signal Transduction >> Cytoskeleton / ECM >> Extracellular Matrix >> ECM Proteins >> Collagen
Signal Transduction >> Cytoskeleton / ECM >> Basal Lamina

Applications

Show applications key

Our Abpromise guarantee covers the use of ab10197 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Target

Function

Polymorphonuclear leukocyte serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) and causes emphysema when administered by tracheal insufflation to hamsters.

Sequence similarities

Belongs to the peptidase S1 family. Elastase subfamily.
Contains 1 peptidase S1 domain.

Target information above from: UniProt accessionP24158 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • ACPA antibody
  • AGP 7 antibody
  • AGP7 antibody
  • AGP7 serine proteinase antibody
  • Azurophil Granule Protein 7 antibody
  • C ANCA antigen antibody
  • C-ANCA antigen antibody
  • EC 3.4.21.76 antibody
  • Leukocyte proteinase 3 antibody
  • MBN antibody
  • MBT antibody
  • MBT WEGENER AUTOANTIGEN antibody
  • Myeloblastin antibody
  • Neutrophil proteinase 4 antibody
  • NP 4 antibody
  • NP-4 antibody
  • NP4 antibody
  • p29 antibody
  • PR 3 antibody
  • PR-3 antibody
  • PR3 antibody
  • Proteinase 3 antibody
  • Proteinase3 antibody
  • PRTN 3 antibody
  • PRTN3 antibody
  • PRTN3_HUMAN antibody
  • Serine Proteinase antibody
  • Serine proteinase neutrophil Wegener granulomatosis autoantigen antibody
  • Wegener Autoantigen antibody
see all

Database links

References for Anti-PR3 antibody [1B10] (ab10197)

This product has been referenced in:

  • Jankowska AMet al. Loss of expression of neutrophil proteinase-3: a factor contributing to thrombotic risk in paroxysmal nocturnal hemoglobinuria. Haematologica 96:954-62 (2011). ELISA; Human.Read more (PubMed: 21546506) »

See 1 publication for this product

Publishing research using ab10197? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"