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Product Name
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PRG2 antibody [1.B.787] - Azide free
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See all PRG2 antibodies (7)...
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Product type
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Primary antibodies
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Description
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Mouse monoclonal [1.B.787] to PRG2 - Azide free
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Immunogen
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Full length protein (Human).
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Reacts with
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Hu
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Does not react with
(species key)
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Ms, Rat, Hrs
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Specificity
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Specific for eosinophil major basic protein(14kD) irrespective of the stages of eosinophil activation and can be regarded as a pan-eosinophil marker.
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Tested applications
(see key)
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IHC-P
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Abreviews
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Application notes
(see key)
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Recommended dilutions
IHC-P: Use at an assay dependent dilution. Perform enzymatic antigen retrieval before commencing with IHC staining protocol.
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Secreted. Note=The proform is secreted. The mature protein is found in the matrix of the eosinophil's large specific granule (crystalloid core).
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Research areas
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Immunology >> Cell Type Markers >> CD >> NK Cells
Immunology >> Adaptive Immunity >> T Cells >> Cytotoxic Cells
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Relevance
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PRG2 is a cytotoxin and helminthotoxin. It also induces noncytolytic histamine release from human basophils and is involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA. In pregnancy serum, the proform exists as a disulfide-linked 2:2 heterotetramer with PAPPA, as a disulfide-linked 2:2 heterotetramer with AGT, and as a complex (probably a 2:2:2 heterohexamer) with AGT and C3dg.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Mouse
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Clonality
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Monoclonal
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Clone number
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1.B.787
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Isotype
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IgG1
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Purity
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Protein A purified
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Storage buffer
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Preservative: None
Constituents: 1mg/ml BSA, PBS, pH 7.2
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Form
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Liquid
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Concentration
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0.100 mg/ml
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Storage instructions
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Add glycerol to a final volume of 50%, aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this PRG2 antibody [1.B.787] - Azide free is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to PRG2
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