You have changed your country from  to  . Please be aware that this will change the currency in the purchasing process.

Reassurance, Refunds & Replacements

If your product does not perform as described on this datasheet, we will refund or replace your product...

Read our guarantee »
 

Anti-PRG2 antibody [1.B.787] - Azide free (ab14463)

CodeSizePriceAbpointsAvailability
     
Add to basket
 
  • -
  •   
  •   
  •   
  •  
  •   
  •   
Updating...

Overview

Product name

Anti-PRG2 antibody [1.B.787] - Azide free
See all PRG2 products (4) ...

Description

Mouse monoclonal [1.B.787] to PRG2 - Azide free

Specificity

Specific for eosinophil major basic protein(14kD) irrespective of the stages of eosinophil activation and can be regarded as a pan-eosinophil marker.

Tested applications

IHC-Pmore details

Cross reactivity

Reacts with

Human

Does not react with

Mouse, Rat, Horse

Immunogen

Full length protein (Human).

Properties

Form

Liquid

Storage instructions

Add glycerol to a final volume of 50%, aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: None
Constituents: 1mg/ml BSA, PBS, pH 7.2

Concentration

Concentration information loading...

Purity

Protein A purified

Clonality

Monoclonal

Clone number

1.B.787

Isotype

IgG1

Research areas

Immunology >> Cell Type Markers >> CD >> NK Cells
Immunology >> Adaptive Immunity >> T Cells >> Cytotoxic Cells

Applications

Show applications key

Our Abpromise guarantee covers the use of ab14463 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • ShowHide

    IHC-P

     IHC-P: Use at an assay d...Read more →

    IHC-P: Use at an assay dependent dilution. Perform enzymatic antigen retrieval before commencing with IHC staining protocol.

Target

Function

Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA.

Tissue specificity

High levels of the proform in placenta and pregnancy serum; in placenta, localized to X cells of septa and anchoring villi. Lower levels in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow and colon.

Sequence similarities

Contains 1 C-type lectin domain.

Developmental stage

Levels of the proform increase in serum and placenta during pregnancy.

Post-translational
modifications

Nitrated.

Cellular localization

Cytoplasmic vesicle > secretory vesicle. The proform is secreted. The mature protein is found in the matrix of the eosinophil's large specific granule and Secreted. The proform is secreted.

Target information above from: UniProt accessionP13727 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • BMPG antibody
  • Bone Marrow Proteoglycan antibody
  • EMBP antibody
  • Eosinophil Granule Major Basic Protein antibody
  • Eosinophil Major Basic Protein antibody
  • MBP antibody
  • MBP1 antibody
  • MGC14537 antibody
  • MPG antibody
  • Natural Killer Cell Activator antibody
  • Pregnancy-associated major basic protein antibody
  • PRG 2 antibody
  • PRG2 antibody
  • PRG2_HUMAN antibody
  • Proteoglycan 2 antibody
  • Proteoglycan 2 bone marrow antibody
  • Proteoglycan 2 Preproprotein antibody
see all

Database links

References for Anti-PRG2 antibody [1.B.787] - Azide free (ab14463)

ab14463 has not yet been referenced specifically in any publications.

Publishing research using ab14463? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"