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Products:Immunology >> Adaptive Immunity >> T Cells >> Cytotoxic Cells
Overview
Product name
Anti-PRG2 antibody [AHE-2]
See all PRG2 products (4) ...
Description
Mouse monoclonal [AHE-2] to PRG2
Specificity
ab78295 reacts with eosinophil major basic protein. It does not cross-react with eosinophil peroxidase, elastase, cathepsin G, esterase N, thrombin, plasmin, kallikrein, lactoferrin, or transferrin. ab78295 stains eosinophils. It does not stain platelets, monocytes, lymphocytes or red blood cells. In some preparations, AHE-2 may faintly stain neutrophils.
Tested applications
ELISA, ICC/IFmore details
Cross reactivity
Reacts with
Human
Immunogen
Protein purified from eosinophils obtained from a patient with hypereosinophilic syndrome.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
Constituents: Ascites
Concentration
Concentration information loading...
Purity
Ascites
Clonality
Monoclonal
Clone number
AHE-2
Isotype
IgG1
Light chain type
kappa
Research areas
Immunology >> Cell Type Markers >> CD >> NK Cells
Immunology >> Adaptive Immunity >> T Cells >> Cytotoxic Cells
Applications
Show applications key
Our Abpromise guarantee covers the use of ab78295 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ELISA
ELISA: 1/800ELISA: 1/800
ICC/IF
ICC/IF: 1/100 - 1/200.ICC/IF: 1/100 - 1/200.
Target
Function
Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA.
Tissue specificity
High levels of the proform in placenta and pregnancy serum; in placenta, localized to X cells of septa and anchoring villi. Lower levels in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow and colon.
Sequence similarities
Contains 1 C-type lectin domain.
Developmental stage
Levels of the proform increase in serum and placenta during pregnancy.
Post-translational
modifications
Nitrated.
Cellular localization
Cytoplasmic vesicle > secretory vesicle. The proform is secreted. The mature protein is found in the matrix of the eosinophil's large specific granule and Secreted. The proform is secreted.
Target information above from: UniProt accessionP13727
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- BMPG antibody
- Bone marrow proteoglycan antibody
- EMBP antibody
see all
Database links
- Entrez Gene: 5553 Human
- Omim: 605601 Human
- SwissProt: P13727 Human
- Unigene: 512633 Human
References for Anti-PRG2 antibody [AHE-2] (ab78295)
ab78295 has not yet been referenced specifically in any publications.
Publishing research using ab78295? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"