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Anti-PRG2 antibody [BMK13]
See all PRG2 products (4) ...
Mouse monoclonal [BMK13] to PRG2
ab77842 is specific for PRG2 irrespective of the stages of eosinophil activation and can be regarded as a "pan-eosinophil" marker. This antibody will recognize the 23.8 kDa secreted pro-form found in the placenta and serum of pregnant women as well as the 13.8 kDa mature form of the protein which is found in the matrix of the eosinophil large specific granule.
WB, ELISA, IHC-P, IHC-Frmore details
Reacts with
Human
Does not react with
Mouse, Rat, Horse
whole isolated human eosinophils
Purified normal human eosinophils.
Liquid
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Preservative: 10mM Sodium Azide
Constituents: PBS, 1mg/ml BSA
Concentration information loading...
Protein A purified
Monoclonal
BMK13
IgG1
Immunology >> Cell Type Markers >> CD >> NK Cells
Immunology >> Adaptive Immunity >> T Cells >> Cytotoxic Cells
Our Abpromise guarantee covers the use of ab77842 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ELISA: Use at an assay dependent dilution.
IHC-P: Use at an assay dependent dilution.
IHC-Fr: Use at an assay dependent dilution.
The antibody reacts better in frozen tissues than in paraffin embedded tissues.
WB: Use at an assay dependent dilution. Predicted molecular weight: 25 kDa.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA.
High levels of the proform in placenta and pregnancy serum; in placenta, localized to X cells of septa and anchoring villi. Lower levels in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow and colon.
Contains 1 C-type lectin domain.
Levels of the proform increase in serum and placenta during pregnancy.
Nitrated.
Cytoplasmic vesicle > secretory vesicle. The proform is secreted. The mature protein is found in the matrix of the eosinophil's large specific granule and Secreted. The proform is secreted.
Target information above from: UniProt accessionP13727
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
ab77842 has not yet been referenced specifically in any publications.
Publishing research using ab77842? Please let us know so that we can cite the reference in this datasheet
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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