Anti-PRMT1 antibody (ab84361)

Overview

• Product nameAnti-PRMT1 antibodySee all PRMT1 primary antibodies ...
• Description
  Rabbit polyclonal to PRMT1
• Tested applicationsIHC-P more details
• Species reactivity
  Reacts with: Mouse, Human
  
• Immunogen

  Synthetic peptide corresponding to a region between residue 300 and the C terminus (residue 361) of Human PRMT1 (accession number: NP_001527.2)

• Positive controlHuman prostate adenocarcinoma; mouse squamous cell carcinoma

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Storage bufferPreservative: 0.09% Sodium Azide
  Constituents: 0.1% BSA, Tris buffered saline
• Concentration information loading...
• PurityImmunogen affinity purified
• Purification notesPurified using an epitope specific to PRMT1 immobilized on solid support.
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Cancer
  • Cell cycle
  • Cell cycle inhibitors
  • p53 pathway

  • Epigenetics and Nuclear Signaling
  • Transcription
  • Co-factors

  • Epigenetics and Nuclear Signaling
  • Nuclear Signaling Pathways
  • Nuclear Receptors
  • Co-activators/co-repressors

  • Epigenetics and Nuclear Signaling
  • Chromatin Modifying Enzymes
  • Methylation
  • Arginine Methylation

  • Epigenetics and Nuclear Signaling
  • Cell cycle
  • Cell Cycle Inhibitors
  • p53

  • Cell Biology
  • Cell Cycle
  • Cell Cycle Inhibitors
  • p53

Applications

Target

• FunctionArginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15 and EWS. Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. Together with dimethylated PIAS1, represses STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway.
• Tissue specificityWidely expressed.
• Sequence similaritiesBelongs to the protein arginine N-methyltransferase family.
• Cellular localizationNucleus. Cytoplasm > cytosol.

Target information above from: UniProt accession Q99873 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 3276 Human
  • Entrez Gene: 15469 Mouse
  • Omim: 602950 Human
  • SwissProt: Q99873 Human
  • SwissProt: Q9JIF0 Mouse
  • Unigene: 20521 Human
  • Unigene: 27545 Mouse

• Alternative names
  ANM 1 antibodyANM1 antibodyANM1_HUMAN antibody

  HCP 1 antibodyHCP1 antibodyHeterogeneous nuclear ribonucleoprotein methyltransferase 1 like 2 antibodyHeterogeneous nuclear ribonucleoproteins methyltransferase like 2 antibodyHeterogeneous nuclear ribonucleoproteins methyltransferase like2 antibodyHistone-arginine N-methyltransferase PRMT1 antibodyHMT 2 antibodyHMT1 (hnRNP methyltransferase S. cerevisiae) like 2 antibodyHMT1 hnRNP methyltransferase antibodyHMT1 hnRNP methyltransferase like 2 (S. cerevisiae) antibodyHMT1 hnRNP methyltransferase like 2 antibodyHMT2 antibodyHRMT1 L2 antibodyHRMT1L 2 antibodyHRMT1L2 antibodyHuman mRNA for suppressor for yeast mutant antibodyHuman mRNA for suppressor for yeast mutant complete cds antibodyInterferon receptor 1 bound protein 4 antibodyInterferon receptor 1 bound protein4 antibodyInterferon receptor 1-bound protein 4 antibodyInterferon receptor 1bound protein 4 antibodyIR1 B4 antibodyIR1B 4 antibodyIR1B4 antibodyMrmt 1 antibodyMrmt1 antibodyPRMT 1 antibodyPRMT1 antibodyProtein arginine methyltransferase 1 antibodyProtein arginine N methyltransferase 1 antibodyProtein arginine N methyltransferase1 antibodyProtein arginine N-methyltransferase 1 antibodyR1B4 antibodyS. cerevisiae like 2 antibody

  see all

Anti-PRMT1 antibody images

• 

  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - PRMT1 antibody (ab84361)
  Detection of Human PRMT1 in formalin-fixed paraffin-embedded section of Human prostate adenocarcinoma by Immunohistochemistry using ab84361 at a dilution of 1/250. Detection was performed by DAB staining using anti-Rabbit IHC antibody at a dilution of 1/100.
• 

  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - PRMT1 antibody (ab84361)
  Detection of Mouse PRMT1 in formalin-fixed paraffin-embedded section of Mouse squamous cell carcinoma by Immunohistochemistry using ab84361 at a dilution of 1/250. Detection was performed by DAB staining using anti-Rabbit IHC antibody at a dilution of 1/100.