Anti-PRMT8 antibody (ab168134)
Key features and details
- Mouse polyclonal to PRMT8
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-PRMT8 antibody -
Description
Mouse polyclonal to PRMT8 -
Host species
Mouse -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse -
Immunogen
Recombinant full length protein within Human PRMT8 aa 1-400. The exact immunogen sequence used to generate this antibody is proprietary information. If additional detail on the immunogen is needed to determine the suitability of the antibody for your needs, please contact our Scientific Support team to discuss your requirements.
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Positive control
- PRMT8 transfected 293T cell lysate.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
Storage buffer
pH: 7.4
Constituent: 99% PBS -
Concentration information loading...
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Purity
Protein A purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab168134 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
Use a concentration of 1 µg/ml. Predicted molecular weight: 45 kDa.
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Notes |
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WB
Use a concentration of 1 µg/ml. Predicted molecular weight: 45 kDa. |
Target
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Function
Membrane-associated arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA). Able to mono- and dimethylate EWS protein; however its precise role toward EWS remains unclear as it still interacts with fully methylated EWS. -
Tissue specificity
Brain-specific. -
Sequence similarities
Belongs to the protein arginine N-methyltransferase family. PRMT8 subfamily. -
Domain
The SH3-binding motifs mediate the interaction with SH3 domain-containing proteins such as PRMT2 and FYN, possibly leading to displace the N-terminal domain and activate the protein.
The N-terminal region (1-60) inhibits the enzymatic activity. -
Cellular localization
Cell membrane. - Information by UniProt
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Database links
- Entrez Gene: 56341 Human
- Entrez Gene: 381813 Mouse
- Omim: 610086 Human
- SwissProt: Q9NR22 Human
- SwissProt: Q6PAK3 Mouse
- Unigene: 504530 Human
- Unigene: 39750 Mouse
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Alternative names
- ANM8_HUMAN antibody
- Heterogeneous nuclear ribonucleoprotein methyltransferase like protein 4 antibody
- Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4 antibody
see all
Images
Datasheets and documents
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Datasheet download
References (1)
ab168134 has been referenced in 1 publication.
- Kagoya Y et al. Arginine methylation of FOXP3 is crucial for the suppressive function of regulatory T cells. J Autoimmun 97:10-21 (2019). PubMed: 30318155