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IHC-P - PSAP antibody (ab55624)
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Western blot - PSAP antibody (ab55624)
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Product Name
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PSAP antibody
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See all PSAP antibodies (4)...
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Product type
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Primary antibodies
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Description
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Mouse monoclonal to PSAP
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Immunogen
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Recombinant full length protein, corresponding to amino acids 18-525 of Human PSAP
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Reacts with
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Hu
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Tested applications
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IHC-P, WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
WB: Use at a concentration of 1-5 µg/ml.
IHC-P: Use at a concentration of 5 µg/ml.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Lysosome
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Research areas
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Signal Transduction >> Metabolism >> Lipid metabolism
Signal Transduction >> Metabolism >> Energy Metabolism
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Relevance
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PSAP is a highly conserved glycoprotein which is a precursor for 4 cleavage products: saposins A, B, C, and D, which are similar to each other and are sphingolipid hydrolase activator proteins. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in PSAP gene have been associated with Gaucher disease, Tay-Sachs disease, and metachromatic leukodystrophy.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Mouse
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Clonality
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Monoclonal
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Isotype
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IgG2a
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Light chain type
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kappa
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Purity
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Protein G purified
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Storage buffer
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Preservative: None
PBS, pH 7.2
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Form
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Liquid
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Concentration
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1.000 mg/ml
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Storage instructions
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this PSAP antibody is on this datasheet. But please do contact us if you would like any reassurance! |
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See below for PSAP antibody images, references, products related to ab55624 and other tools.
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PSAP antibody images:
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 IHC-P - PSAP antibody (ab55624)
PSAP antibody (ab55624) used in immunohistochemistry at 5ug/ml on formalin fixed and paraffin embedded human spleen tissue.
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Western blot - PSAP antibody (ab55624)
Predicted band size : 58 kDa
Observed band size : 58 kDa
Additional bands at : 48 kDa. We are unsure as to the identity of these extra bands.
Western Blot analysis of PSAP expression in transfected 293T cell line by PSAP monoclonal antibody.
Lane 1: PSAP transfected lysate.
Lane 2: Non-transfected lysate.
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Search PubMed (MEDLINE) for references to PSAP
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PSAP antibody - more information
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Customer reviews (feedback) regarding PSAP antibody |
Customer FAQs regarding PSAP antibody |
Protocols for PSAP antibody |
Price and availability of products related to PSAP antibody |
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PSAP antibody - related products:
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PSAP antibody - other tools:
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Contact Abcam with a Technical Enquiry about PSAP antibody |
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All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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