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Read our guarantee »Overview
Product name
PSF2 protein (T7 Tag)
Protein description
Recombinant full length protein of Human PSF2 with a T7 tag at N-terminus.
Expression host
E. coli
Properties
Purity
> 95% by SDS-PAGE
Form
Liquid
Storage instructions
Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 0.002% Sodium Azide
Constituents: 0.1% Triton-X-100, 10mM Tris, pH 8
Concentration
Concentration information loading...
Research areas
Cell Biology >> Cell Cycle >> Cell Division >> Other cell division antibodies
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SDS-PAGE - PSF2 protein (ab40232)
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Applications
Show applications key
Our Abpromise guarantee covers the use of ab40232 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
SDS-PAGE: Use at an assay dependent dilution.
MS: Use at an assay dependent dilution.
Protein info
Relevance
The GINS complex is composed of four subunits, encoded by SLD5, PSF1, PSF2, and PSF3. In S. cerevisiae, it was first identified by genetic and biochemical methods to determine factors interacting with Sld5p. Genetic interactions between these four genes also suggest that they act together. The GINS complex was independently isolated in a large scale screen for cell cycle defects. A similar complex is found in Xenopus and has a ring-like structure. In yeast, all four genes are essential and cells defective in SLD5, PSF1, or PSF2 are impaired in their ability to replicate DNA. The complex localizes to origins of DNA replication and Sld5p was previously implicated as functioning in DNA replication due to its genetic interaction with DPB11. Additional genetic and biochemical interactions of the GINS complex with Dpb11p, Dpb2p, and Sld3p suggest that it functions in some way at the replication fork during DNA synthesis (1).
Cellular localization
Nuclear
PSF2 protein (T7 Tag) images:
SDS-PAGE - PSF2 protein (ab40232)
Analysis of PSF2 Recombinant Protein (1µg). 4-20% SDS gradient gel. Coomassie blue staining. The purified PSF2 protein shows a band around 25kDa.
References for PSF2 protein (T7 Tag) (ab40232)
ab40232 has not yet been referenced specifically in any publications.
Publishing research using ab40232? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"