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Products:Cell Biology >> Proteolysis / Ubiquitin >> Proteasome / Ubiquitin >> Proteasome
Overview
Product name
Anti-PSMB5 antibody
See all PSMB5 products (5) ...
Description
Rabbit polyclonal to PSMB5
Tested applications
WB, ELISAmore details
Cross reactivity
Reacts with
Mouse
Immunogen
Synthetic peptide corresponding to N terminal residues of mouse PSMB5.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer
Preservative: 0.01% Sodium Azide
Constituents: 50% Glycerol, PBS
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Purification notes
Purified by antigen specific affinity chromatography.
Clonality
Polyclonal
Isotype
IgG
Research areas
Cell Biology >> Proteolysis / Ubiquitin >> Proteasome / Ubiquitin >> Proteasome
Applications
Show applications key
Our Abpromise guarantee covers the use of ab55888 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB
ELISA
Application notes
ELISA: Use at an assay dependent dilution.
WB: Use at a concentration of 1 µg/ml for 2hrs. Predicted molecular weight: 23 kDa.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Function
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This unit is responsible of the chymotrypsin-like activity of the proteasome and is one of the principal target of the proteasome inhibitor bortezomib. May catalyze basal processing of intracellular antigens. Plays a role in the protection against oxidative damage throught the Nrf2-ARE pathway.
Sequence similarities
Belongs to the peptidase T1B family.
Cellular localization
Cytoplasm. Nucleus.
Target information above from: UniProt accessionP28074
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- DKFZp459C139 antibody
- EC 3.4.25.1 antibody
- LMPX antibody
see all
Database links
- Entrez Gene: 19173 Mouse
- SwissProt: O55234 Mouse
- Unigene: 8911 Mouse
References for Anti-PSMB5 antibody (ab55888)
This product has been referenced in:
- de Verteuil Det al. Deletion of immunoproteasome subunits imprints on the transcriptome and has a broad impact on peptides presented by major histocompatibility complex I molecules. Mol Cell Proteomics 9:2034-47 (2010). WB; Mouse.Read more (PubMed: 20484733) »
See 1 publication for this product
Publishing research using ab55888? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"