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Product Name 

PTP mu antibody [SK15]

 

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Product type 

Primary antibodies

Description 

Mouse monoclonal [SK15] to PTP mu

Immunogen 

Human PTP mu.

Reacts with 

Hu

Does not react with 
(species key)

Ms, Rat

Specificity 

ab30321 recognises Tyrosine Phosphatase Mu.

Tested applications 
(see key)

IP, WB


Abreviews 

Customer reviews
(see key)


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Application notes 
(see key)

Recommended dilutions
IP: Use at a concentration of 1.0 µg/sample.
WB: Use at a concentration of 2.5 µg/ml. Predicted molecular weight: 162 kDa.


Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Cellular localization 

Type 1 membrane protein

Research areas 

Signal Transduction >> Protein Phosphorylation >> Tyrosine Phosphatases

Relevance 

PTP mu is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion.

 

PTP mu antibody [SK15] (ab30321)

Database links 

The links below go to external sites and will open in a new browser window

Entrez Gene

    

5797    (Human)

Omim

    

176888    (Human)

SwissProt

    

P28827    (Human)
Q86V60    (Human)
Q49AC9    (Human)

Unigene

    

49774    (Human)

Raised in 

Mouse

Clonality 

Monoclonal

Clone number 

SK15

Myeloma 

Sp2/0

Isotype 

IgG1

Purity 

Protein A purified

Storage buffer 

Preservative: 0.01% Sodium Azide
Constituents: 50% Glycerol, 1.0mg/ml BSA

Material safety datasheets (MSDS) for this product:
Glycerol MSDS
Sodium Azide MSDS

Purification notes 

IgG is protein A purified and dialyzed against PBS.

Form 

Liquid

Concentration 

1.000 mg/ml

Storage instructions 

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

 

At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this PTP mu antibody [SK15] is on this datasheet. But please do contact us if you would like any reassurance!


 

Search PubMed (MEDLINE) for references to PTP mu

 

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