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Product name
PTP mu protein (Tagged)
See all PTP mu products (3) ...
Protein description
Recombinant fragment, corresponding to Internal sequence amino acids 839-1100 of Human PTP mu containing the catalytic domain and with an N terminal tag. M.Wt 56 kDa.
Expression host
E. coli
Properties
Purity
> 95% by SDS-PAGE
Biological activity
680 U/ug. One unit will hydrolyze 1 pmol p-nitrophenyl phosphate per minute at pH 7.4 and 30°C. Assay buffer: 50 mM HEPES, pH 7.4, 2 mM EDTA, 3mM DTT, 100 mM NaCl, 50 mM pNPP.
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
Storage buffer
Preservative: None
Constituents: 50% Glycerol, 0.05% Tween 20, 75mM Sodium chloride, 25mM Tris HCl, 2mM EDTA, 10mM Glutathione, 1mM DTT, pH 8.0
Concentration
Concentration information loading...
Research areas
Signal Transduction >> Protein Phosphorylation >> Tyrosine Phosphatases
Applications
Show applications key
Our Abpromise guarantee covers the use of ab42589 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Inhibition Assay
Application notes
Inhib: Use at an assay dependent dilution. Useful for the study of enzyme kinetics, regulation, and to dephosphorylate target substrates.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Protein info
Function
Involved in cell-cell adhesion through homophilic interactions. May play a key role in signal transduction and growth control.
Sequence similarities
Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.
Contains 4 fibronectin type-III domains.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 MAM domain.
Contains 2 tyrosine-protein phosphatase domains.
Cellular localization
Membrane.
Target information above from: UniProt accessionP28827
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
References for PTP mu protein (Tagged) (ab42589)
ab42589 has not yet been referenced specifically in any publications.
Publishing research using ab42589? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"