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Overview

  • Product namePTP4A1 protein (Tagged)See all PTP4A1 proteins and peptides ...
  • Protein descriptionRecombinant full length protein, corresponding to amino acids 2-173 of Human PTP4A1, with N-terminal proprietary tag
  • Expression hostE. coli

    • Properties

  • Purity> 95 % by SDS-PAGE
  • Biological activity0.45 U/ug. One unit will hydrolyze 1 pmol 6, 8-difluoro-4-methyl umbelliferyl phosphate (DiFMUP) per minute at pH 6.3 and 30?C. Assay buffer: 50 mM Bis-Tris, pH 6.3, 2 mM EDTA, 2 mM DTT, 100 mM DiFMUP.
  • FormLiquid
  • Storage instructionsAliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: 50% Glycerol, 0.05% Tween 20, 75mM Sodium chloride, 25mM Tris HCl, 2mM EDTA, 10mM Glutathione, 1mM DTT, pH 8
  • Concentration information loading...
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab42567 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    Inhibition Assay
  • Application notesInhib: Use at an assay dependent dilution. Useful for the study of enzyme kinetics, regulation, to dephosphorylate target substrates and for screening inhibitors.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.

    • Protein info

    • Alternative names
        HH 72HH72HH72
        Hypothetical protein DKFZp779M0721Hypothetical protein DKFZp779M0721PRL 1PRL-1PRL1PRL1Protein tyrosine phosphatase PTPCAAX1Protein tyrosine phosphatase type IVA 1Protein tyrosine phosphatase type IVA member 1Protein tyrosine phosphatase type IVA member 1Protein-tyrosine phosphatase 4a1Protein-tyrosine phosphatase of regenerating liver 1PTP(CAAXI)Ptp4a1PTPCAAX1PTPCAAX1TP4A1_HUMAN
      see all
  • FunctionProtein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis.
  • Tissue specificityExpressed in bone marrow, lymph nodes, T lymphocytes, spleen, thymus and tonsil. Overexpressed in tumor cell lines.
  • Sequence similaritiesBelongs to the protein-tyrosine phosphatase family.
    Contains 1 tyrosine-protein phosphatase domain.
  • Developmental stageExpressed in fetal liver.
  • Post-translational
    modifications    Farnesylated. Farnesylation is required for membrane targeting. Unfarnesylated forms are shifted into the nucleus.
  • Cellular localizationCell membrane. Early endosome. Endoplasmic reticulum. Cytoplasm. Cytoplasm > cytoskeleton > spindle. And mitotic spindle.

    • Target information above from: UniProt accession Q93096 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    References for PTP4A1 protein (Tagged) (ab42567)

    ab42567 has not yet been referenced specifically in any publications.

    Publishing research using ab42567 ? Please let us know so that we can cite the reference in this datasheet

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