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Overview

  • Product namePTPD2 peptideSee all PTPD2 proteins and peptides ...
  • Protein descriptionSynthetic peptide derived from within residues 900 - 1000 PTPD2. (Note: the amino acid sequence is proprietary).
  • Protein length1187 amino acids

    • Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferInformation available upon request.
  • Concentration information loading...
  • Research Areas

    • Protein info

    • Alternative names
        Cytoskeletal associated protein tyrosine phosphataseMGC126803PEZ
        Phosphatase with ezrin domainProtein tyrosine phosphatase non receptor type 14protein tyrosine phosphatase non-receptor type 14Protein tyrosine phosphatase pezProtein-tyrosine phosphatase pezPTN14_HUMANPTP 36PTP36PTPD 2PTPD2PTPN 14PTPN14Tyrosine protein phosphatase non receptor type 14Tyrosine-protein phosphatase non-receptor type 14
      see all
  • FunctionProtein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis.
  • Tissue specificityExpressed in a variety of human tissues including kidney, skeletal muscle, lung and placenta.
  • Involvement in diseaseDefects in PTPN14 are a cause of choanal atresia and lymphedema (CHATLY) [MIM:613611]. A disease characterized by posterior choanal atresia and lymphedema. Additional features are a high-arched palate, hypoplastic nipples, and mild pectus excavatum. Note=A homozygous deletion in PTPN14 predicted to result in frameshift and premature truncation, has been shown to be the cause of choanal atresia and lymphedema in one family.
  • Sequence similaritiesBelongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
    Contains 1 FERM domain.
    Contains 1 tyrosine-protein phosphatase domain.
  • Post-translational
    modifications    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localizationCytoplasm > cytoskeleton.

    • Target information above from: UniProt accession Q15678 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    References for PTPD2 peptide (ab12578)

    ab12578 has not yet been referenced specifically in any publications.

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