You have changed your country from  to  . Please be aware that this will change the currency in the purchasing process.

Overview

  • Product namePXR protein (Human)See all PXR proteins and peptides ...
  • Protein descriptionRecombinant full length human PXR expressed in baculovirus system; amino acids 1-434, 50kDa. Swiss ID = O75469.
  • Expression hostBaculovirus

    • Properties

  • Purification notesab82082 is purified by an affinity column in combination with FPLC chromatography and is greater than 95% homogeneous. ab82082 contains no detectable proteases, DNase and RNase activity.
  • Biological activity1 unit equals 1 nanogram of purified protein. ab82082 binds to DNA as a heterodimer with RXR alpha; 1000U (1ug) required.
  • FormLiquid
  • Storage instructionsShipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: 20% Glycerol, 20mM Tris Cl, 100mM Potassium chloride, 1mM DTT, 0.2mM EDTA, pH 8.0
  • Concentration information loading...
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab82082 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    Gel supershift assays
  • Application notesGSA: Use at an assay dependent dilution.
    Protein-protein ineraction assay: Use 100 units.
    Small molecules-protein interactions assay: Use at an assay dependent dilution.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.

    • Protein info

    • Alternative names
        BXRNR1I2NR1I2_HUMAN
        Nuclear receptor subfamily 1 group I member 2ONR 1ONR1Orphan nuclear receptor PAR 1Orphan nuclear receptor PAR1Orphan nuclear receptor PXROTTHUMP00000215173OTTHUMP00000215174OTTHUMP00000215175PARPAR 1PAR 2PAR qPAR1PAR2PARqpregnane X nuclear receptor variant 2Pregnane X receptorPRRPXRSARSteroid and xenobiotic receptorSXR
      see all
  • FunctionNuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes.
  • Tissue specificityExpressed in liver, colon and small intestine.
  • Sequence similaritiesBelongs to the nuclear hormone receptor family. NR1 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • Cellular localizationNucleus.

    • Target information above from: UniProt accession O75469 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    References for PXR protein (Human) (ab82082)

    ab82082 has not yet been referenced specifically in any publications.

    Publishing research using ab82082 ? Please let us know so that we can cite the reference in this datasheet

    Product Wall

    Submit an Abreview for ab82082 Submit a Question for ab82082

    There are currently no Abreviews or Questions for ab82082.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"