Overview

  • Product namePentoxifylline
  • Description
    Phosphodiesterase inhibitor. Cytokine inhibitor.
  • Alternative names
    • oxpentifylline
    • PTX
  • Biological descriptionPhosphodiesterase inhibitor. Inhibits synthesis of TNF-α. Broad-spectrum inhibitor of cytokines. Displays anti-inflammatory and antinociceptive properties.
  • Purity> 99%

Properties

    Applications

    Our Abpromise guarantee covers the use of ab120725 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    Functional Studies Use at an assay dependent concentration.

    Pentoxifylline images

    • ab54775 staining annexin V in HeLa cells treated with pentoxifylline (ab120725), by ICC/IF. Increase of annexin V correlates with increased concentration of pentoxifylline, as described in literature.
      The cells were incubated at 37°C for 24h in media containing different concentrations of ab120725 (pentoxifylline) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab54775 (10 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-mouse polyclonal antibody (ab96879) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

    References for Pentoxifylline (ab120725)

    This product has been referenced in:
    • Wei T  et al. Pentoxifylline attenuates nociceptive sensitization and cytokine expression in a tibia fracture rat model of complex regional pain syndrome. Eur J Pain 13:253-62 (2009). Read more (PubMed: 18554967) »
    • Vale ML  et al. Antihyperalgesic effect of pentoxifylline on experimental inflammatory pain. Br J Pharmacol 143:833-44 (2004). Read more (PubMed: 15520047) »
    • Mandell GL Cytokines, phagocytes, and pentoxifylline. J Cardiovasc Pharmacol 25 Suppl 2:S20-2 (1995). Read more (PubMed: 8699856) »

    See 0 Publications for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"