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Products:Cardiovascular >> Lipids / Lipoproteins >> Adipose Related >> Lipid Droplet Protein
Overview
Product name
Anti-Perilipin A+B antibody
See all Perilipin A+B products (2) ...
Description
Rabbit polyclonal to Perilipin A+B
Tested applications
Cross reactivity
Reacts with
Mouse
Predicted to work with
Rat, Human
Immunogen
Synthetic Peptide: M(1)SMNKGPTLLDGDLPEQ(17)C . Immunizing peptide corresponds to amino acid residues 1-17 from rat Perilipin A and B. This sequence is 82% conserved in humans.
MSMNKGPTLL DGDLPEQ-C
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
PBS with 0.05% sodium azide
Concentration
Concentration information loading...
Purity
IgG fraction
Clonality
Polyclonal
Isotype
IgG
Research areas
Cancer >> Cancer Metabolism >> Metabolic signaling pathway >> Metabolism of lipids and lipoproteins
Cardiovascular >> Atherosclerosis >> Lipoprotein metabolism
Signal Transduction >> Metabolism >> Lipid metabolism
Cardiovascular >> Lipids / Lipoproteins >> Adipose Related >> Lipid Droplet Protein
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Western blot - Perilipin A+B antibody (ab3527)
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Applications
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Our Abpromise guarantee covers the use of ab3527 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: 1/1000
Target
Relevance
Perilipin is an intracellular neutral lipid droplet protein that is hormonally regulated. This protein is localized exclusively to the surface of lipid droplets. In response to lypotic stimuli, perilipin is phosphorylated by protein kinase A. Once activated, perilipin has inhibitory affects upon hormone-sensitive lipase (HSL), a protein that mediates the hydrolysis of triacylglycerol, the major form of stored energy in the body. Perilipin expression is limited to adipocytes and steroidogenic cells. There are currently two known isoforms, Perilipin A and B. Both of these proteins are encoded by a single-copy gene and are the result of differential splicing events.
Cellular localization
Lipid droplet
Alternative names
- Lipid droplet associated protein antibody
- PERIA antibody
- PERIB antibody
see all
Database links
- Entrez Gene: 5346 Human
- Entrez Gene: 103968 Mouse
- Entrez Gene: 25629 Rat
- Omim: 170290 Human
- SwissProt: O60240 Human
- SwissProt: Q8CGN5 Mouse
- SwissProt: P43884 Rat
- Unigene: 103253 Human
Anti-Perilipin A+B antibody images:
Western blot - Perilipin A+B antibody (ab3527)
Anti-Perilipin A+B antibody (ab3527) + Cell extracts prepared from 3T3-L1 cells
References for Anti-Perilipin A+B antibody (ab3527)
This product has been referenced in:
- Matushansky Iet al. A developmental model of sarcomagenesis defines a differentiation-based classification for liposarcomas. Am J Pathol 172:1069-80 (2008). WB; Human.Read more (PubMed: 18310505) »
- Fernández-Veledo Set al. HYPERINSULINEMIA INDUCES INSULIN RESISTANCE ON GLUCOSE AND LIPID METABOLISM IN A HUMAN ADIPOCYTIC CELL LINE: PARACRINE INTERACTION WITH MYOCYTES. J Clin Endocrinol Metab : (2008).Read more (PubMed: 18430774) »
See all 2 publications for this product
Publishing research using ab3527? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"