Peroxiredoxin 1 antibody (ab15571)

Product Name 

Peroxiredoxin 1 antibody

Product type 

Primary antibodies

Description 

Rabbit polyclonal to Peroxiredoxin 1

Immunogen 

Synthetic peptide: LVSDPKRTIAQD, corresponding to amino acids 103-114 of Human Peroxiredoxin 1.
BLAST 'LVSDPKRTIAQD' with or

Reacts with 

Hu

Predicted to react 
(species key)

Ms, Rat, ChHm, Cow
(Due to sequence homology)

Specificity 

This antibody detects Peroxiredoxin 1 protein in human samples. The antibody is specific for Peroxiredoxin 1 and shows no cross reactivity with other Prx isoforms.

Tested applications 
(see key)

ICC, WB

Abreviews 

Customer reviews (see key)

Read about Abreviews (Read all Abreviews)

Application notes 
(see key)

Recommended dilutions
ICC: 1/500.
WB: 1/10000. Detects a band of approximately 26 kDa protein representing Prx 1 in human PC3 cell lysate (predicted molecular weight: 22 kDa).


Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Positive control 
(see definition)

TSU Pr1 cells for cell staining, human PC3 cell lysate for western blotting.

Cellular localization 

Cytoplasmic

Research areas 

Cardiovascular >> Atherosclerosis >> Vascular Inflammation >> Inflammatory mediators
Cell Biology >> Other Antibodies >> Other Antibodies
Cell Biology >> Other Antibodies >> Oxidative Stress

Relevance 

Peroxiredoxin 1 is involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H2O2. It is constitutively expressed in most human cells; is induced to higher levels upon serum stimulation in untransformed and transformed cells.

Database links 

Raised in 

Rabbit

Clonality 

Polyclonal

Isotype 

IgG

Purity 

Whole antiserum

Storage buffer 

Preservative: 0.05% Sodium Azide
Constituents: Whole serum

Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS

Form 

Liquid

Concentration 

Concentration not determined - why is this?

Storage instructions 

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

See below for Peroxiredoxin 1 antibody images, references, products related to ab15571 and other tools.

Peroxiredoxin 1 antibody images:

References for Peroxiredoxin 1 antibody (ab15571)

  This product has been used in: (two most recent references)

Giusti L et al. Fine-needle aspiration of thyroid nodules: proteomic analysis to identify cancer biomarkers. J Proteome Res 7:4079-88 (2008). WB; Human. PubMed: 18665625

Odreman F et al. Proteomic studies on low- and high-grade human brain astrocytomas. J Proteome Res 4:698-708 (2005). PubMed: 15952716

See all 3 publication references for this product.


If you publish research using ab15571 please let us know so that we can cite the reference on this datasheet.

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