Anti-Phospholamban (phospho S16) antibody [EPR1911] (ab92697)
- Product nameAnti-Phospholamban (phospho S16) antibody [EPR1911]See all Phospholamban primary antibodies ...
- DescriptionRabbit monoclonal [EPR1911] to Phospholamban (phospho S16)
- Tested applicationsWB, IP more details
- Species reactivityReacts with: Mouse, Human
Does not react withRat
A phospho specific peptide corresponding to residues surrounding Serine 16 of Human Phospholamban.
- Positive controlFetal heart lysate
- General notesProduced under U.S. Patent No. 5,675,063.
- Storage instructionsStore at -20°C. Stable for 12 months at -20°C
- Storage bufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
- PurityTissue culture supernatant
- Purification notesThis antibody is not purified. It is provided in cell supernatant and storage buffer.
- Clonality Monoclonal
- Clone numberEPR1911
Our Abpromise guarantee covers the use of ab92697 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: 1/200,000 - 1/500,000. Detects a band of approximately 11 kDa (predicted molecular weight: 6 kDa).
Is unsuitable for IHC-P.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
- FunctionPhospholamban has been postulated to regulate the activity of the calcium pump of cardiac sarcoplasmic reticulum.
- Tissue specificityHeart.
- Involvement in diseaseDefects in PLN are the cause of cardiomyopathy dilated type 1P (CMD1P) [MIM:609909]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
Defects in PLN are the cause of cardiomyopathy familial hypertrophic type 18 (CMH18) [MIM:613874]. CMH18 is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
- Sequence similaritiesBelongs to the phospholamban family.
modificationsPhosphorylated in response to beta-adrenergic stimulation.
- Cellular localizationMitochondrion membrane. Sarcoplasmic reticulum.
- Cardiac phospholamban antibodyCMD1P antibodyCMH18 antibody
- PLB antibodyPLN antibodyPPLA_HUMAN antibody
Anti-Phospholamban (phospho S16) antibody [EPR1911] images
All lanes : Anti-Phospholamban (phospho S16) antibody [EPR1911] (ab92697) at 1/200000 dilution
Lane 1 : Fetal heart lysate (untreated)
Lane 2 : Fetal heart lysate (treated with LP)
Lysates/proteins at 10 µg per lane.
HRP labelled Goat anti-Rabbit antibody at 1/2000 dilution
Predicted band size : 6 kDa
References for Anti-Phospholamban (phospho S16) antibody [EPR1911] (ab92697)
ab92697 has not yet been referenced specifically in any publications.