RabMAb

Anti-Phospholamban (phospho S16) antibody [EPR1911] (ab92697)

Overview

  • Product nameAnti-Phospholamban (phospho S16) antibody [EPR1911]See all Phospholamban primary antibodies ...
  • Description
    Rabbit monoclonal [EPR1911] to Phospholamban (phospho S16)
  • Tested applicationsWB, IPmore details
  • Species reactivity
    Reacts with: Mouse, Human

    Does not react with

    Rat
  • Immunogen

    A phospho specific peptide corresponding to residues surrounding Serine 16 of Human Phospholamban.

  • Positive control
    • Fetal heart lysate
  • General notesProduced under U.S. Patent No. 5,675,063.

Properties

Applications

Our Abpromise guarantee covers the use of ab92697 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
IP
  • Application notesIP: 1/50.
    WB: 1/200,000 - 1/500,000. Detects a band of approximately 11 kDa (predicted molecular weight: 6 kDa).

    Is unsuitable for IHC-P.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionPhospholamban has been postulated to regulate the activity of the calcium pump of cardiac sarcoplasmic reticulum.
    • Tissue specificityHeart.
    • Involvement in diseaseDefects in PLN are the cause of cardiomyopathy dilated type 1P (CMD1P) [MIM:609909]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
      Defects in PLN are the cause of cardiomyopathy familial hypertrophic type 18 (CMH18) [MIM:613874]. CMH18 is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
    • Sequence similaritiesBelongs to the phospholamban family.
    • Post-translational
      modifications
      Phosphorylated in response to beta-adrenergic stimulation.
    • Cellular localizationMitochondrion membrane. Sarcoplasmic reticulum.
    • Information by UniProt
    • Database links
    • Alternative names
      • Cardiac phospholamban antibody
      • CMD1P antibody
      • CMH18 antibody
      • PLB antibody
      • PLN antibody
      • PPLA_HUMAN antibody
      see all

    Anti-Phospholamban (phospho S16) antibody [EPR1911] images

    • All lanes : Anti-Phospholamban (phospho S16) antibody [EPR1911] (ab92697) at 1/200000 dilution

      Lane 1 : Fetal heart lysate (untreated)
      Lane 2 : Fetal heart lysate (treated with LP)

      Lysates/proteins at 10 µg per lane.

      Secondary
      HRP labelled Goat anti-Rabbit antibody at 1/2000 dilution

      Predicted band size : 6 kDa

    References for Anti-Phospholamban (phospho S16) antibody [EPR1911] (ab92697)

    ab92697 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"