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Products:Cardiovascular >> Lipids / Lipoproteins >> Lipid Metabolism >> Lipases
Overview
Product name
Anti-Phospholipase A2 XII antibody
See all Phospholipase A2 XII products (3) ...
Description
Rabbit polyclonal to Phospholipase A2 XII
Specificity
This antibody is specific for Phospholipase A2 XII.
Tested applications
ELISA, WBmore details
Cross reactivity
Reacts with
Human
Immunogen
Recombinant human Phospholipase A2 XII. 20.6 kDa protein containing 167 amino acid residues of the human Phospholipase A2 XII and 16 additional amino acid residues, HisTag. Source of immunogen E.coli
Properties
Form
Liquid
Storage instructions
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
Constituents: 0.1M Sodium chloride, 0.05M PBS, pH 7.2
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Purification notes
Immunoaffinity chromatography on a column with immobilized recombinant human Phospholipase A2 XII.
Clonality
Polyclonal
Isotype
IgG
Research areas
Signal Transduction >> Metabolism >> Lipid metabolism
Cardiovascular >> Lipids / Lipoproteins >> Lipid Metabolism >> Lipases
Applications
Show applications key
Our Abpromise guarantee covers the use of ab47121 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ELISA: Use at an assay dependent dilution.
WB: Use a concentration of 1 µg/mlPredicted molecular weight: 21 kDa.
Target
Relevance
Phospholipase A2 catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to liberate arachidonic acid, a precursor of eicosanoids including prostaglandins and leukotrienes. This enzyme has been proposed to hydrolyze phosphatidylcholine (PC) in lipoproteins to liberate lyso-PC and free fatty acids in the arterial wall, thereby facilitating the accumulation of bioactive lipids and modified lipoproteins in atherosclerotic foci.
Cellular localization
Cytoplasmic and Secreted
Alternative names
- EC 3.1.1.4 antibody
- Group XIIA secretory phospholipase A2 precursor antibody
- GXII sPLA2 antibody
see all
Database links
- Entrez Gene: 81579 Human
- Omim: 611652 Human
- SwissProt: Q9BZM1 Human
References for Anti-Phospholipase A2 XII antibody (ab47121)
ab47121 has not yet been referenced specifically in any publications.
Publishing research using ab47121? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"