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AbcamBiochemicals (Asc-478)

Pifithrin-α-HBr (ab120478)

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Overview

  • Product namePifithrin-α-HBr
  • Description
    p53 inhibitor
  • Biological descriptionp53 inhibitor. Specifically blocks tumour supressor p53 transcriptional activity and can supress heat shock and glucocorticoid signalling pathways. Additionally offers protection to cells from p53 mediated apoptosis. Active in vivo; protects mice from chemotherapy side effects associated with p53 induction. Also aryl hydrocarbon receptor (AHR) agonist.
  • Purity> 98%
  • General notes

    Pifithrin-α-HBr is light senstive and it is recommended that the compound is protected from light.

    • Properties

  • Chemical name1-(4-Methylphenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)ethanone hydrobromide
  • Molecular Weight367.30
  • Chemical structureChemical Structure
  • Molecular formulaC16H18N2OS.HBr
  • CAS Number63208-82-2
  • PubChem identifier9929138
  • Storage instructionsStore at -20°C (desiccating conditions).
  • Solubility overviewSoluble in DMSO to 100 mM
  • Handling

    Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

  • SMILESBr.Cc1ccc(cc1)C(=O)CN2C=3CCCCC=3SC2=N
  • Source

    Synthetic

  • Research Areas

    • References for Pifithrin-α-HBr (ab120478)

    This product has been referenced in:
    • Sohn D  et al. Pifithrin-alpha protects against DNA damage-induced apoptosis downstream of mitochondria independent of p53. Cell Death Differ 16:869-78 (2009). Read more (PubMed: 19229248) »
    • Hoagland MS  et al. The p53 inhibitor pifithrin-alpha is a potent agonist of the aryl hydrocarbon receptor. J Pharmacol Exp Ther 314:603-10 (2005). Read more (PubMed: 15843497) »
    • Komarova EA  et al. p53 inhibitor pifithrin alpha can suppress heat shock and glucocorticoid signaling pathways. J Biol Chem 278:15465-8 (2003). Read more (PubMed: 12637507) »
    • Komarov PG  et al. A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. Science 285:1733-7 (1999). Read more (PubMed: 10481009) »

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"