Overview

Properties

Applications

Our Abpromise guarantee covers the use of ab57289 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionTranscriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene; the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation of alternative pre-mRNA splicing. Associates to spliced mRNA within 60 nt upstream of the 5'-splice sites. Involved in the establishment and maintenance of epithelia cell-cell adhesion. Potential tumor suppressor for renal cell carcinoma.
    • Tissue specificityExpressed in placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon, heart, epidermis, esophagus, brain and smooth and skeletal muscle. Expressed strongly in melanoma metastasis lesions and advanced primary tumors.
    • Sequence similaritiesBelongs to the pinin family.
    • Post-translational
      modifications
      Phosphorylated upon DNA damage, probably by ATM or ATR.
    • Cellular localizationNucleus speckle. Cell junction > desmosome. Cell-cell contact area, predominantly desmosome of intercellular adherens junction. Not a nucleocytoplasmic shuttling protein.
    • Target information above from: UniProt accession Q9H307 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links
    • Alternative names
      • 140 kDa nuclear and cell adhesion-related phosphoprotein antibody
      • Desmosome-associated protein antibody
      • Domain-rich serine protein antibody
      • DRS antibody
      • DRS protein antibody
      • DRSP antibody
      • Melanoma metastasis clone A protein antibody
      • MEMA antibody
      • Nuclear protein SDK3 antibody
      • Pinin antibody
      • PININ_HUMAN antibody
      • PNN antibody
      • SR like protein antibody
      • SR-like protein antibody
      see all

    Anti-Pinin antibody images



    • Predicted band size : 81 kDa
      Pinin antibody (ab57289) at 1ug/lane + PC-12 cell lysate at 25ug/lane.

    References for Anti-Pinin antibody (ab57289)

    ab57289 has not yet been referenced specifically in any publications.

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