Anti-Pinin antibody (ab57289)

Overview

• Product nameAnti-Pinin antibodySee all Pinin primary antibodies ...
• Description
  Mouse monoclonal to Pinin
• Tested applicationsWB more details
• Species reactivity
  Reacts with: Rat, Human
  
• Immunogen

  Recombinant fragment: AKQTELRLLE QKVELAQLQE EWNEHNAKII KYIRTKTKPH LFYIPGRMCP ATQKLIEESQ RKMNALFEGR RIEFAEQINK MEARPRRQSM KEKEHQVVRN , corresponding to amino acids 201-301 of Human Pinin

  Run BLAST with Run BLAST with

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Storage bufferPreservative: None
  PBS, pH 7.2
• Concentration information loading...
• PurityProtein G purified
• Clonality Monoclonal
• IsotypeIgG2a
• Light chain typekappa
• Research Areas
  • Cancer
  • Oncoproteins/suppressors
  • Tumor suppressors
  • Other

  • Epigenetics and Nuclear Signaling
  • Transcription
  • Domain Families
  • HLH / Leucine Zipper
  • HLH

  • Epigenetics and Nuclear Signaling
  • Transcription
  • Cancer susceptibility
  • Tumor Suppressors

  • Epigenetics and Nuclear Signaling
  • Transcription
  • Transcription Factors

  • Epigenetics and Nuclear Signaling
  • DNA / RNA
  • RNA Processing
  • Splicing

Applications

Target

• FunctionTranscriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene; the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation of alternative pre-mRNA splicing. Associates to spliced mRNA within 60 nt upstream of the 5'-splice sites. Involved in the establishment and maintenance of epithelia cell-cell adhesion. Potential tumor suppressor for renal cell carcinoma.
• Tissue specificityExpressed in placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon, heart, epidermis, esophagus, brain and smooth and skeletal muscle. Expressed strongly in melanoma metastasis lesions and advanced primary tumors.
• Sequence similaritiesBelongs to the pinin family.
• Post-translational
  modificationsPhosphorylated upon DNA damage, probably by ATM or ATR.
• Cellular localizationNucleus speckle. Cell junction > desmosome. Cell-cell contact area, predominantly desmosome of intercellular adherens junction. Not a nucleocytoplasmic shuttling protein.

Target information above from: UniProt accession Q9H307 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 5411 Human
  • Entrez Gene: 368070 Rat
  • Omim: 603154 Human
  • SwissProt: Q9H307 Human
  • Unigene: 409965 Human

• Alternative names
  140 kDa nuclear and cell adhesion-related phosphoprotein antibodyDesmosome-associated protein antibodyDomain-rich serine protein antibody

  DRS antibodyDRS protein antibodyDRSP antibodyMelanoma metastasis clone A protein antibodyMEMA antibodyNuclear protein SDK3 antibodyPinin antibodyPININ_HUMAN antibodyPNN antibodySR like protein antibodySR-like protein antibody

  see all

Anti-Pinin antibody images

• 

  Western blot - Pinin antibody (ab57289)
  
  
  Predicted band size : 81 kDa
  Pinin antibody (ab57289) at 1ug/lane + PC-12 cell lysate at 25ug/lane.