Recombinant Anti-Pirin/PIR antibody [EPR11375(B)] (ab157212)
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [EPR11375(B)] to Pirin/PIR
- Suitable for: WB
- Reacts with: Human
Related conjugates and formulations
Overview
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Product name
Anti-Pirin/PIR antibody [EPR11375(B)]
See all Pirin/PIR primary antibodies -
Description
Rabbit monoclonal [EPR11375(B)] to Pirin/PIR -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details
Unsuitable for: Flow Cyt,ICC/IF,IHC-P or IP -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat -
Immunogen
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
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Positive control
- MCF7, HeLa, A431 and A375 cell lysates.
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General notes
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
pH: 7.2
Preservative: 0.01% Sodium azide
Constituents: 9% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, 50% Tissue culture supernatant -
Concentration information loading...
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Purity
Tissue culture supernatant -
Clonality
Monoclonal -
Clone number
EPR11375(B) -
Isotype
IgG -
Research areas
Associated products
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Alternative Versions
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Isotype control
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Positive Controls
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Recombinant Protein
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Related Products
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab157212 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/1000 - 1/10000. Predicted molecular weight: 32 kDa.
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Notes |
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WB
1/1000 - 1/10000. Predicted molecular weight: 32 kDa. |
Target
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Function
Possible transcriptional coregulator. May contribute to the regulation of cellular processes via its interaction with BCL3. May be required for efficient terminal myeloid maturation of hematopoietic cells. May play a role in the regulation of cell migration. May promote apoptosis when overexpressed. Has quercetin 2,3-dioxygenase activity (in vitro). -
Tissue specificity
Highly expressed in a subset of melanomas. Detected at very low levels in most tissues (at protein level). Expressed in all tissues, with highest level of expression in heart and liver. -
Pathway
Flavonoid metabolism; quercetin degradation. -
Sequence similarities
Belongs to the pirin family. -
Cellular localization
Nucleus. Cytoplasm. Predominantly localized in dot-like subnuclear structures. Cytoplasmic localization of PIR seems to positively correlate with melanoma progression. - Information by UniProt
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Database links
- Entrez Gene: 8544 Human
- Entrez Gene: 69656 Mouse
- Entrez Gene: 363465 Rat
- Omim: 603329 Human
- SwissProt: O00625 Human
- SwissProt: Q9D711 Mouse
- SwissProt: Q5M827 Rat
- Unigene: 495728 Human
see all -
Alternative names
- 3-dioxygenase PIR antibody
- Iron binding nuclear protein antibody
- Pir antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab157212 has not yet been referenced specifically in any publications.