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Read our guarantee »Products:Cell Biology >> Proteolysis / Ubiquitin >> Proteolytic enzymes >> Serine protease >> Kallikreins
Anti-Plasma Kallikrein 1B antibody - Apple Domain 2
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Rabbit polyclonal to Plasma Kallikrein 1B - Apple Domain 2
ab43084 recognizes the zymogen form of plasma kallikrein and the heavy chain of factor XIIa cleaved plasma kallikrein, but not the kallikrein heavy chain, and can be used to distinguish the two forms.
Reacts with
Mouse, Rat, Human
(Peptide available as ab43117.)
Liquid
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Preservative: 0.5% Sodium Azide
Constituents: 50% Glycerol
Concentration information loading...
Immunogen affinity purified
Peptide-affinity purified.
Polyclonal
IgG
Cell Biology >> Proteolysis / Ubiquitin >> Proteolytic enzymes >> Serine protease >> Kallikreins
Our Abpromise guarantee covers the use of ab43084 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: 1/1000Predicted molecular weight: 71 kDa.(A 1/5000 dilution is recommended for chemiluminescent substrates. Higher concentrations of antibody may be needed for samples from more distantly related species. EDTA/EGTA treatment of tissues or lysates is required to see latent zymogen. Glycosylation and other post translational modifications give plasma kallikrein a higher apparent molecular weights of 88 and 85 kDa Dilution optimised using Chromogenic detection.)
The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.
Defects in KLKB1 are the cause of prekallikrein deficiency (PKK deficiency) [MIM:612423]; also known as Fletcher factor deficiency. This disorder is a blood coagulation defect.
Belongs to the peptidase S1 family. Plasma kallikrein subfamily.
Contains 4 apple domains.
Contains 1 peptidase S1 domain.
Secreted.
Target information above from: UniProt accessionP03952
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
ab43084 has not yet been referenced specifically in any publications.
Publishing research using ab43084? Please let us know so that we can cite the reference in this datasheet
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