Prazosin hydrochloride, Peripheral alpha adrenoceptor antagonist (ab120238)
Key features and details
- Peripheral α adrenoceptor antagonist. Melatonin antagonist.
- CAS Number: 19237-84-4
- Soluble in DMSO to 25 mM and in ethanol to 5 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Prazosin hydrochloride, Peripheral alpha adrenoceptor antagonist -
Description
Peripheral α adrenoceptor antagonist. Melatonin antagonist. -
Biological description
Peripheral α1 and α2 adrenoceptor antagonist. Orally active vasodilator. Also melatonin MT3 antagonist.
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CAS Number
19237-84-4 -
Chemical structure
Properties
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Chemical name
[4-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl]-2-furanylmethanone hydrochloride -
Molecular weight
419.86 -
Molecular formula
C19H21N5O4.HCl -
PubChem identifier
68546 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 25 mM and in ethanol to 5 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Cl.O=C(N1CCN(CC1)c3nc2cc(OC)c(OC)cc2c(N)n3)c4ccco4 -
Source
Synthetic
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Research areas
Images
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (2)
ab120238 has been referenced in 2 publications.
- Tyurin-Kuzmin PA et al. Activation of ß-adrenergic receptors is required for elevated a1A-adrenoreceptors expression and signaling in mesenchymal stromal cells. Sci Rep 6:32835 (2016). PubMed: 27596381
- Meitzen J et al. ß1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons. J Neurochem 116:984-95 (2011). PubMed: 21143600