Overview

  • Product nameAnti-Prealbumin antibodySee all Prealbumin primary antibodies ...
  • Description
    Rabbit polyclonal to Prealbumin
  • Specificityab50776 reacts with human prealbumin.
  • Tested applicationsIHC-P, IHC-Frmore details
  • Species reactivity
    Reacts with: Sheep, Goat, Horse, Chicken, Cow, Cat, Dog, Human
  • Immunogen

    Prealbumin isolated from human serum.

  • Positive control
    • Human colon or tonsil tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab50776 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
IHC-Fr
  • Application notesIHC-Fr: 1/50 - 1/100.
    IHC-P: 1/50 - 1/100.
    Trypsin digestion of paraffin sections is recommended. 60 minutes primary antibody incubation at 25oC. Standard ABC technique.

    Is unsuitable for WB.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionThyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.
    • Tissue specificityDetected in serum and cerebrospinal fluid (at protein level). Highly expressed in choroid plexus epithelial cells. Detected in retina pigment epithelium and liver.
    • Involvement in diseaseDefects in TTR are the cause of amyloidosis transthyretin-related (AMYL-TTR) [MIM:105210]. A hereditary generalized amyloidosis due to transthyretin amyloid deposition. Protein fibrils can form in different tissues leading to amyloid polyneuropathies, amyloidotic cardiomyopathy, carpal tunnel syndrome, systemic senile amyloidosis. The disease includes leptomeningeal amyloidosis that is characterized by primary involvement of the central nervous system. Neuropathologic examination shows amyloid in the walls of leptomeningeal vessels, in pia arachnoid, and subpial deposits. Some patients also develop vitreous amyloid deposition that leads to visual impairment (oculoleptomeningeal amyloidosis). Clinical features include seizures, stroke-like episodes, dementia, psychomotor deterioration, variable amyloid deposition in the vitreous humor.
      Defects in TTR are a cause of hyperthyroxinemia dystransthyretinemic euthyroidal (HTDE) [MIM:145680]. It is a condition characterized by elevation of total and free thyroxine in healthy, euthyroid persons without detectable binding protein abnormalities.
      Defects in TTR are a cause of carpal tunnel syndrome type 1 (CTS1) [MIM:115430]. It is a condition characterized by entrapment of the median nerve within the carpal tunnel. Symptoms include burning pain and paresthesias involving the ventral surface of the hand and fingers which may radiate proximally. Impairment of sensation in the distribution of the median nerve and thenar muscle atrophy may occur. This condition may be associated with repetitive occupational trauma, wrist injuries, amyloid neuropathies, rheumatoid arthritis.
    • Sequence similaritiesBelongs to the transthyretin family.
    • DomainEach monomer has two 4-stranded beta sheets and the shape of a prolate ellipsoid. Antiparallel beta-sheet interactions link monomers into dimers. A short loop from each monomer forms the main dimer-dimer interaction. These two pairs of loops separate the opposed, convex beta-sheets of the dimers to form an internal channel.
    • Cellular localizationSecreted. Cytoplasm.
    • Information by UniProt
    • Database links
    • Alternative names
      • Amyloid polyneuropathy antibody
      • Amyloidosis I antibody
      • ATTR antibody
      • Carpal tunnel syndrome 1 antibody
      • CTS antibody
      • CTS1 antibody
      • Dysprealbuminemic euthyroidal hyperthyroxinemia antibody
      • Dystransthyretinemic hyperthyroxinemia antibody
      • Epididymis luminal protein 111 antibody
      • HEL111 antibody
      • HsT2651 antibody
      • PALB antibody
      • Prealbumin amyloidosis type I antibody
      • Prealbumin antibody
      • Prealbumin Thyroxine-binding antibody
      • Senile systemic amyloidosis antibody
      • TBPA antibody
      • Thyroxine binding prealbumin antibody
      • Transthyretin antibody
      • TTHY_HUMAN antibody
      • TTR antibody
      • TTR protein antibody
      see all

    Anti-Prealbumin antibody images

    • ab50776 at 1/50 dilution staining human prealbulin in human small cell carcinoid tumor by Immunohistochemistry, Paraffin embedded tissue. (Note cytoplasmic staining of tumor cells).

    References for Anti-Prealbumin antibody (ab50776)

    ab50776 has not yet been referenced specifically in any publications.

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