Anti-Presenilin 1 + 2 antibody (ab60120)

Overview

• Product nameAnti-Presenilin 1 + 2 antibody
• Description
  Rabbit polyclonal to Presenilin 1 + 2
• Tested applicationsELISA, WB more details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  Synthetic peptide (10-30 aa in length) conjugated to KLH, in the region of amino acids 126-143 of Human Presenilin 1 and Presenilin 2.

• Positive controlHela cell lysate.

Properties

• FormLiquid
• Storage instructionsStore at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles.
• Storage bufferPreservative: 0.09% Sodium Azide
  Constituents: PBS
• Concentration information loading...
• PurityProtein G purified
• Purification notesab60120 is purified through a protein G column and eluted out with both high and low pH buffers and neutralized immediately after elution, followed by dialysis against PBS.
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Metabolism
  • Types of disease
  • Neurodegenerative disease

  • Metabolism
  • Types of disease
  • Cancer

  • Metabolism
  • Pathways and Processes
  • Metabolism processes
  • Hypoxia

  • Metabolism
  • Pathways and Processes
  • Metabolism processes
  • Autophagy and mitophagy

  • Cancer
  • Cancer Metabolism
  • Response to hypoxia

  • Cancer
  • Signal transduction
  • Autophagy

  • Neuroscience
  • Neurology process
  • Neurodegenerative disease
  • Alzheimer's disease
  • Proteases

  • Neuroscience
  • Neurology process
  • Notch Pathway

Applications

Target

• RelevanceAlzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP.
• Cellular localizationEndoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cell surface.
• Database links
  • Entrez Gene: 5663 Human
  • Entrez Gene: 5664 Human
  • Omim: 104311 Human
  • Omim: 600759 Human
  • SwissProt: P49768 Human
  • SwissProt: P49810 Human
  • Unigene: 592324 Human
  • Unigene: 25363 Human

• Alternative names
  AD 3 antibodyAD4 antibodyAD5 antibody

  Alzheimer disease 3 antibodyAlzheimer disease 4 antibodyFAD antibodyPresenilin 1 antibodyPresenilin 2 antibodyPresenilin1 antibodyPS1 antibodyPS2 antibodyPSEN1 antibodyPSEN2 antibodySTM2 antibody

  see all

Anti-Presenilin 1 + 2 antibody images

• 

  Western blot - Presenilin 1 + 2 antibody (ab60120)
  Anti-Presenilin 1 + 2 antibody (ab60120) at 1/100 dilution + Hela cell lysate at 35 µg
  
  Predicted band size : 53 kDa
  Observed band size : 55 kDa (why is the actual band size different from the predicted?)