Anti-Presenilin 2 antibody - N-terminal (ab60121)

Overview

• Product nameAnti-Presenilin 2 antibody - N-terminalSee all Presenilin 2 primary antibodies ...
• Description
  Rabbit polyclonal to Presenilin 2 - N-terminal
• Tested applicationsELISA, WB more details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  Synthetic peptide from the N-terminal region (Human) conjugated to KLH

• Positive controlMouse kidney tissue lysate.

Properties

• FormLiquid
• Storage instructionsStore at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles.
• Storage bufferPreservative: 0.09% Sodium Azide
  Constituents: PBS
• Concentration information loading...
• PurityProtein G purified
• Purification notesab60121 is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Metabolism
  • Types of disease
  • Neurodegenerative disease

  • Metabolism
  • Types of disease
  • Cancer

  • Metabolism
  • Pathways and Processes
  • Metabolism processes
  • Hypoxia

  • Cancer
  • Cancer Metabolism
  • Response to hypoxia

  • Neuroscience
  • Neurology process
  • Notch Pathway

  • Neuroscience
  • Neurology process
  • Neurodegenerative disease
  • Alzheimer's disease
  • Proteases

Applications

Target

• FunctionProbable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins.
• Tissue specificityIsoform 1 is seen in the placenta, skeletal muscle and heart while isoform 2 is seen in the heart, brain, placenta, liver, skeletal muscle and kidney.
• Involvement in diseaseDefects in PSEN2 are the cause of Alzheimer disease type 4 (AD4) [MIM:606889]. AD is an autosomal dominant Alzheimer disease. Alzheimer disease is a neurodegenerative disorder characterized by progressive dementia, loss of cognitive abilities, and deposition of fibrillar amyloid proteins as intraneuronal neurofibrillary tangles, extracellular amyloid plaques and vascular amyloid deposits. The major constituent of these plaques is the neurotoxic amyloid-beta-APP 40-42 peptide (s), derived proteolytically from the transmembrane precursor protein APP by sequential secretase processing. The cytotoxic C-terminal fragments (CTFs) and the caspase-cleaved products such as C31 derived from APP, are also implicated in neuronal death.
  Defects in PSEN2 are the cause of cardiomyopathy dilated type 1V (CMD1V) [MIM:613697]. It is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
• Sequence similaritiesBelongs to the peptidase A22A family.
• DomainThe PAL motif is required for normal active site conformation.
• Post-translational
  modificationsHeterogeneous proteolytic processing generates N-terminal and C-terminal fragments.
  Phosphorylated on serine residues.
• Cellular localizationEndoplasmic reticulum membrane. Golgi apparatus membrane.

Target information above from: UniProt accession P49810 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 5664 Human
  • Omim: 600759 Human
  • SwissProt: P49810 Human
  • Unigene: 25363 Human

• Alternative names
  AD 3L antibodyAD 3LP antibodyAD 4 antibody

  AD 5 antibodyAD3L antibodyAD3LP antibodyAD4 antibodyAD5 antibodyAlzheimer disease 4 antibodyAlzheimer disease familial type 4 antibodyAlzheimer's disease 3 like antibodyCMD1V antibodyE5 1 antibodyE5-1 antibodyEC 3.4.23. antibodyOTTHUMP00000035671 antibodyOTTHUMP00000035672 antibodyOTTHUMP00000228286 antibodyOTTHUMP00000228288 antibodyPresenilin 2 (Alzheimer disease 4) antibodyPresenilin 2 antibodyPresenilin-2 CTF subunit antibodyPresenilin2 antibodyPS 2 antibodyPS-2 antibodyPS2 antibodyPSEN 2 antibodyPsen2 antibodyPSN2_HUMAN antibodyPSNL 2 antibodyPSNL2 antibodySTM 2 antibodySTM-2 antibodySTM2 antibody

  see all

Anti-Presenilin 2 antibody - N-terminal images

• 

  Western blot - Presenilin 2 antibody - N-terminal (ab60121)
  Anti-Presenilin 2 antibody - N-terminal (ab60121) at 1/50 dilution + Mouse kidney tissue lysate at 35 µg
  
  Predicted band size : 50 kDa
  Observed band size : 50 kDa