Overview

  • Product nameAnti-Presenilin 2 antibodySee all Presenilin 2 primary antibodies ...
  • Description
    Goat polyclonal to Presenilin 2
  • SpecificityAb11148 recognises human Presenilin-2, binding to neurons in both normal and Alzheimer's disease brain.
  • Tested applicationsIHC-Fr, IHC-P, ELISA more details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide, corresponding to amino acids 31-47 of Human Presenilin 2.

  • Positive control
    • Brain.
  • General notesThis product should be stored undiluted. Storage in frost free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.

Properties

Applications

Our Abpromise guarantee covers the use of ab11148 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
IHC-Fr
IHC-P
ELISA
  • Application notesELISA: 1/20000 on immunising peptide.
    IHC-P: 1/300.
    IHC-Fr: 1/1000.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionProbable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins.
    • Tissue specificityIsoform 1 is seen in the placenta, skeletal muscle and heart while isoform 2 is seen in the heart, brain, placenta, liver, skeletal muscle and kidney.
    • Involvement in diseaseDefects in PSEN2 are the cause of Alzheimer disease type 4 (AD4) [MIM:606889]. AD is an autosomal dominant Alzheimer disease. Alzheimer disease is a neurodegenerative disorder characterized by progressive dementia, loss of cognitive abilities, and deposition of fibrillar amyloid proteins as intraneuronal neurofibrillary tangles, extracellular amyloid plaques and vascular amyloid deposits. The major constituent of these plaques is the neurotoxic amyloid-beta-APP 40-42 peptide (s), derived proteolytically from the transmembrane precursor protein APP by sequential secretase processing. The cytotoxic C-terminal fragments (CTFs) and the caspase-cleaved products such as C31 derived from APP, are also implicated in neuronal death.
      Defects in PSEN2 are the cause of cardiomyopathy dilated type 1V (CMD1V) [MIM:613697]. It is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
    • Sequence similaritiesBelongs to the peptidase A22A family.
    • DomainThe PAL motif is required for normal active site conformation.
    • Post-translational
      modifications
      Heterogeneous proteolytic processing generates N-terminal and C-terminal fragments.
      Phosphorylated on serine residues.
    • Cellular localizationEndoplasmic reticulum membrane. Golgi apparatus membrane.
    • Target information above from: UniProt accession P49810 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links
    • Alternative names
      • AD 4 antibody
      • AD3L antibody
      • AD3LP antibody
      • AD4 antibody
      • AD5 antibody
      • Alzheimer disease 4 antibody
      • Alzheimer Disease Familial Type 4 antibody
      • Alzheimer's disease 3 like antibody
      • CMD1V antibody
      • E5 1 antibody
      • E5-1 antibody
      • OTTHUMP00000035671 antibody
      • OTTHUMP00000035672 antibody
      • OTTHUMP00000228286 antibody
      • OTTHUMP00000228288 antibody
      • Presenilin 2 (Alzheimer disease 4) antibody
      • Presenilin 2 antibody
      • Presenilin-2 CTF subunit antibody
      • PS 2 antibody
      • PS-2 antibody
      • PS2 antibody
      • PSEN 2 antibody
      • PSEN2 antibody
      • PSN2_HUMAN antibody
      • PSNL2 antibody
      • STM-2 antibody
      • STM2 antibody
      see all

    Anti-Presenilin 2 antibody images

    • Paraffin embedded mouse kidney stained with Goat anti Human Presenilin-2 (ab11148) followed by rabbit anti goat IgG:HRP

    References for Anti-Presenilin 2 antibody (ab11148)

    ab11148 has not yet been referenced specifically in any publications.

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