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Products:Cardiovascular >> Blood >> Other
Overview
Product name
Procalcitonin protein
See all Procalcitonin products (2) ...
Protein description
Recombinant 114 amino acid fragment, corresponding to the unprocessed procalcitonin protein, amino acids 3-116, of Human Procalcitonin with an amino-terminal hexahistidine tag.
Expression host
E. coli
Properties
Purity
>95% by SDS-PAGE
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer
Preservative: None
Constituents: 50% Glycerol, 20mM Tris, pH 8
Concentration
Concentration information loading...
Research areas
Signal Transduction >> Growth Factors/Hormones >> Hormones
Cardiovascular >> Blood >> Other
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SDS-PAGE - Procalcitonin protein (ab53369)
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Applications
Show applications key
Our Abpromise guarantee covers the use of ab53369 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
SDS-PAGE: Use at an assay dependent dilution.
Protein info
Relevance
Procalcitonin (PCT) is a 116 amino acid residue peptide with molecular weight of about 13 kDa. PCT itself has no known hormonal activity. PCT belongs to a group of related proteins including calcitonin gene-related peptides I and II, amylin, adrenomodulin and calcitonin (CAPA peptide family). PCT, like other peptides of CAPA family, appears from the common precursor pre-procalcitonin consisting of 141 amino acids by removal of 25 amino acids from the N-terminus. PCT undergoes successive cleavages to form three molecules: N-terminal fragment (55 a.a.), calcitonin (32 a.a.) and katacalcin (21 a.a.). Under normal metabolic conditions, PCT is only present in the C cells of the thyroid gland. In bacterial infection and sepsis, however, intact PCT is found in the blood and, more importantly, its level is related to the severity of bacterial sepsis. Today, PCT is considered to be one of the earliest and most specific markers of sepsis.
Cellular localization
Secreted
Procalcitonin protein images:
SDS-PAGE - Procalcitonin protein (ab53369)
SDS-PAGE analysis of ab53369, amino-terminal hexahistidine tagged recombinant procalcitonin.
References for Procalcitonin protein (ab53369)
ab53369 has not yet been referenced specifically in any publications.
Publishing research using ab53369? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"