Procalcitonin protein (ab53369)

Product Name 

Procalcitonin protein

Product type 

Proteins and Peptides

Peptide 

Recombinant 114 amino acid fragment, corresponding to the unprocessed procalcitonin protein, amino acids 3-116, of Human Procalcitonin with an amino-terminal hexahistidine tag.

Tested applications 
(see key)

SDS-PAGE

Application notes 
(see key)

Recommended dilutions
SDS-PAGE: Use at an assay dependent dilution.


Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Research areas 

Signal Transduction >> Growth Factors/Hormones >> Hormones
Cardiovascular >> Blood >> Other

Relevance 

Procalcitonin (PCT) is a 116 amino acid residue peptide with molecular weight of about 13 kDa. PCT itself has no known hormonal activity. PCT belongs to a group of related proteins including calcitonin gene-related peptides I and II, amylin, adrenomodulin and calcitonin (CAPA peptide family). PCT, like other peptides of CAPA family, appears from the common precursor pre-procalcitonin consisting of 141 amino acids by removal of 25 amino acids from the N-terminus. PCT undergoes successive cleavages to form three molecules: N-terminal fragment (55 a.a.), calcitonin (32 a.a.) and katacalcin (21 a.a.).
Under normal metabolic conditions, PCT is only present in the C cells of the thyroid gland. In bacterial infection and sepsis, however, intact PCT is found in the blood and, more importantly, its level is related to the severity of bacterial sepsis. Today, PCT is considered to be one of the earliest and most specific markers of sepsis.

Purity 

>95% by SDS-PAGE

Storage buffer 

Preservative: None
Constituents: 50% Glycerol, 20mM Tris, pH 8

Material safety datasheet (MSDS) for this product:
Glycerol MSDS

Form 

Liquid

Concentration 

Batch dependent within range: 0.10 - 0.10 mg/ml

Concentration of lot no.     is  

Concentration not available for this lot.

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Storage instructions 

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Expression system 

E. coli

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