Loading...
You have changed your country from
to
. Please be aware that this will change the currency in the purchasing process.
Products:Signal Transduction >> Growth Factors/Hormones >> Insulin / Insulin-like
Overview
Product name
Anti-Proprotein Convertase 2 antibody
See all Proprotein Convertase 2 products (6) ...
Description
Rabbit polyclonal to Proprotein Convertase 2
Tested applications
Cross reactivity
Reacts with
Mouse
Predicted to work with
Rat
Immunogen
Synthetic peptide: ELDEAVERSLQSILRKN, corresponding to amino acids 622-638 of Mouse Proprotein Convertase 2(Peptide available as ab5012.).
ELDEAVERSL QSILRKN
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
PBS, 1 mg/ml BSA, 0.05% sodium azide
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Primary antibody notes
The subtilisin-like Prohormone Convertase (PC) family is a group of cellular enzymes that cleave most prohormones and neuropeptide precursors. Numerous other cellular proteins, some viral proteins, and bacterial toxins that are transported by the constitutive secretory pathway are also targeted for maturation by PCs. PC family members share structural similarities, which include a heterogeneous ~10 kDa amino-terminal proregion, a highly conserved ~55 kDa subtilisin-like catalytic domain, and carboxyl-terminal domain that is heterogeneous in length and sequence. These enzymes become catalytically active following proregion cleavage within the appropriate cellular compartment. The subcellular localization of PC family members varies. Immunolocalization studies show that PC1 is found in the perinuclear region as well as the trans-Golgi network, whereas PC2 can be found in the trans-Golgi network as well as diffusely distributed in the peripheral cytoplasm.
Clonality
Polyclonal
Isotype
IgG
Research areas
Cell Biology >> Proteolysis / Ubiquitin >> Proteolytic enzymes >> Serine protease >> Proprotein Convertases
Neuroscience >> Neurology process >> Metabolism
Signal Transduction >> Protein Trafficking >> Nuclear Import / Export
Signal Transduction >> Growth Factors/Hormones >> Hormones
Signal Transduction >> Growth Factors/Hormones >> Insulin / Insulin-like
Applications
Show applications key
Our Abpromise guarantee covers the use of ab3533 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB
Application notes
Western Blot: use at a concentration of 2 µg/ml.
Not tested in other applications.
Optimal dilutions / concentrations should be determined by the end user.
By Western blot, this antibody detects an ~65 kDa protein representing Proprotein 2 from alpha TC 6 cell extract.
Target
Function
Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues.
Sequence similarities
Belongs to the peptidase S8 family. Furin subfamily.
Cellular localization
Cytoplasmic vesicle > secretory vesicle. Localized in the secretion granules.
Target information above from: UniProt accessionP16519
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- KEX2 like endoprotease 2 antibody
- KEX2-like endoprotease 2 antibody
- NEC 2 antibody
see all
Database links
- Entrez Gene: 18549 Mouse
- Entrez Gene: 25121 Rat
- SwissProt: P21661 Mouse
- SwissProt: Q3TYM6 Mouse
- SwissProt: Q3UZV3 Mouse
- SwissProt: Q547J8 Mouse
- SwissProt: Q9D3A4 Mouse
- SwissProt: P28841 Rat
see all
References for Anti-Proprotein Convertase 2 antibody (ab3533)
This product has been referenced in:
- Gagnon Jet al. Expression of PCSK1 (PC1/3), PCSK2 (PC2) and PCSK3 (furin) in mouse small intestine. Regul Pept 152:54-60 (2009).Read more (PubMed: 18706454) »
See 1 publication for this product
Publishing research using ab3533? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"